DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and vasn

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001005036.1	Gene:	vasn / 448556	XenbaseID:	XB-GENE-941552	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	107/422 - (25%)
Similarity:	167/422 - (39%)	Gaps:	92/422 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 VWH-------LATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNI 192
            :||       |||..|:....|.:| |:||.....| |......:.|  :.:|.:.:|:.:..|.
Frog     1 MWHLLVWIILLATAQQMITEGCPAG-CQCNTPQTVF-CLARKNSNFP--RSVPPDTLNLYVFENG 61

  Fly   193 LSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNI 257
            :|::.:.:|.||..|..||:|||.|..||..:|::|.:|..|.:.:|||.:|...||..|..|..
Frog    62 ISSIEESSFIGLNGLHLLDLSHNQLSSLPGGVFRNLANLSNLDLTSNQLTEISADTFQGLSRLER 126

  Fly   258 LDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIR 322
            |.|:.|.|..:....|...:.|..:.:.:||:.. ||......|:|  ||:|.|.|..:..|
Frog   127 LYLNGNRIRSIHPEAFKGIESLLELKLSNNQLVT-PPAFSLPHLLL--LDLSYNAIPVIQQG--- 185

  Fly   323 YLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISH 387
                                                         :| |..|:.:|.|....:..
Frog   186 ---------------------------------------------VF-NAGNIESLRLAGLGLKE 204

  Fly   388 IDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSN-NLTTLEADDFQGLNNLKILL 451
            :.......|.||:||.|..|.:..:|..|    ..||:|.:..| ..:.::.||
Frog   205 VPEELLSGLKNLHELDLSDNQLDKVPPGL----HGLTKLNIAGNVGFSQIQVDD----------- 254

  Fly   452 LNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLAR 516
            |:|             |..|::|.:....|..||.|.....|.|.||.|.:||::|.|...:|:.
Frog   255 LSN-------------LPALQELDLSGLSLQTLPKGLFRSSKRLRAVSLAQNPFNCVCSLGWLSE 306

  Fly   517 WIREFVLKLWDGQQPMCRGPGDLGGHEVGLLR 548
            |:|...:.|....:..|..|....|..:..||
Frog   307 WMRVSGVVLLRPDETRCHFPPKNAGKTLRQLR 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	47/184 (26%)
		leucine-rich repeat	207..230	CDD:275380	11/22 (50%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	7/57 (12%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	0/22 (0%)
		LRR_8	349..407	CDD:290566	11/57 (19%)
		LRR_4	350..390	CDD:289563	5/39 (13%)
		leucine-rich repeat	351..374	CDD:275380	2/22 (9%)
		leucine-rich repeat	375..398	CDD:275380	3/22 (14%)
		LRR_8	398..>443	CDD:290566	14/45 (31%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/20 (30%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	13/46 (28%)
vasn	NP_001005036.1	LRRNT	21..52	CDD:214470	9/34 (26%)
		leucine-rich repeat	52..75	CDD:275380	6/22 (27%)
		LRR 1	52..72		4/19 (21%)
		LRR	<60..>276	CDD:227223	71/295 (24%)
		LRR 2	75..96		10/20 (50%)
		leucine-rich repeat	76..99	CDD:275380	11/22 (50%)
		LRR_8	99..158	CDD:338972	17/58 (29%)
		LRR 3	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 4	123..144		6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR 5	147..168		5/21 (24%)
		leucine-rich repeat	148..169	CDD:275380	5/21 (24%)
		LRR 6	169..189		9/70 (13%)
		leucine-rich repeat	170..191	CDD:275380	9/71 (13%)
		LRR 7	191..212		3/20 (15%)
		leucine-rich repeat	192..215	CDD:275380	3/22 (14%)
		LRR 8	215..237		8/25 (32%)
		leucine-rich repeat	216..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..260	CDD:275380	9/47 (19%)
		LRR 9	238..258		6/43 (14%)
		LRR 10	259..281		6/21 (29%)
		leucine-rich repeat	261..281	CDD:275380	6/19 (32%)
		PCC	265..>344	CDD:188093	22/74 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..395
		EGF	407..438	CDD:333761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910