DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and znf534

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_012823677.1	Gene:	znf534 / 448416	XenbaseID:	XB-GENE-1219092	Length:	423	Species:	Xenopus tropicalis

Alignment Length:	261	Identity:	55/261 - (21%)
Similarity:	90/261 - (34%)	Gaps:	71/261 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLLMDPAEVITG---PS-------QAKEPP------------IQSLDEFRQRYLLP--------L 46
            |:|.|.|.:.||   ||       |.|..|            .|:|.:|...:.:|        .
Frog   101 VILPDTAHLRTGLYRPSKTFTVLPQVKTEPGSNFAQPCSASLTQTLPDFTSVFSMPHSVAVNNIF 165

  Fly    47 ISSDT-RNCSLNACES-------LGIVSQLLMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNG 103
            |..:. ....|:|..|       :.:.::.|.|..|  :||.|..|       ..:|......||
Frog   166 IKQEAPSEVPLSAPASIQPQVYPMSMANETLSLAQS--SGTTSVVN-------SISGVTMATHNG 221

  Fly   104 GEINAMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTS--GVCRCNPDTKSFTCW 166
            |. :.:...|....||:.:.:...:..|....:| :.|..:..:...|  |.....|:     ..
Frog   222 GP-SPLPQPARIQQVKQYQTLGQDVVPVSGQFYH-SPGVSLPPSPPNSQPGSPENQPE-----LM 279

  Fly   167 NT-----------NLKSVPVTQV--IPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            ||           .||.|....:  :|.:||::.....::.|:.|...|....|::..|.|  .|
Frog   280 NTISPPPSYEATFGLKLVQPQHIHTVPSSMVSVLPQGQVIMTVPKYNRRNNPELEKRRIHH--CD 342

  Fly   219 F 219
            |
Frog   343 F 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	10/38 (26%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	6/19 (32%)
		leucine-rich repeat	207..230	CDD:275380	5/13 (38%)
		leucine-rich repeat	231..254	CDD:275380
		LRR_8	253..313	CDD:290566
		leucine-rich repeat	255..278	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	303..361	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR_8	349..407	CDD:290566
		LRR_4	350..390	CDD:289563
		leucine-rich repeat	351..374	CDD:275380
		leucine-rich repeat	375..398	CDD:275380
		LRR_8	398..>443	CDD:290566
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	423..443	CDD:275380
		leucine-rich repeat	471..494	CDD:275380
		LRRCT	503..554	CDD:214507
znf534	XP_012823677.1	Meiotic_rec114	<169..287	CDD:367544	25/133 (19%)
		COG5048	<246..>423	CDD:227381	22/106 (21%)
		C2H2 Zn finger	344..363	CDD:275368	55/261 (21%)
		C2H2 Zn finger	371..393	CDD:275368
		zf-H2C2_2	385..410	CDD:372612
		C2H2 Zn finger	401..421	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940