DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo1b

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001004576.1	Gene:	lingo1b / 447837	ZFINID:	ZDB-GENE-040912-136	Length:	622	Species:	Danio rerio

Alignment Length:	432	Identity:	115/432 - (26%)
Similarity:	186/432 - (43%)	Gaps:	38/432 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LVKRVRQIESRLRSVEQPVWHLATGSQIEWN--HCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVI 179
            :|.|.....|.|.:..||:..|..|:.:..:  .|.|. |.|:...:|..|....|.::|  :.|
Zfish    10 MVAREASGHSYLVACWQPILILMLGTVLSGSATGCPSR-CECSAQERSVVCHRRKLITLP--EGI 71

  Fly   180 PMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDI 244
            |::...:|||:|.|..::.:.|.....|::|.::.|::..:....|.:|..|..|.::||.|:.|
Zfish    72 PIDTRLLDLSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLI 136

  Fly   245 DHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMS 309
            ....|..|.||..||:|:|:|.:|.:.:|.....|..:.:.||.:.............||:|.|.
Zfish   137 QLGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAFHGLSSLEQLTME 201

  Fly   310 RNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHN-NRISSLSGTIFNNLA 373
            |..::.:.:.:..:|..|.||......:..|.|..|..|..|:.|.:.| ..:.||:....:.|
Zfish   202 RCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGL- 265

  Fly   374 NLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEA 438
            |:.||.:|...::.:...|...|..|....|..|.:..:..:...|:..|....|....|.::|.
Zfish   266 NITTLSITNCNLTAVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVGGRLVSIEP 330

  Fly   439 DDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            ..|:|||.|::                        |.:.||.|..|...|.|.:.||..:.|..|
Zfish   331 YSFKGLNYLRV------------------------LNVSSNSLSTLEESAFHSVGNLETLALHDN 371

  Fly   504 PWHCDCRALYL--ARWIREFVLKLWDGQQPMCRGPGDLGGHE 543
            |..||||.|::  .||...|     :.|||.|..|..|.|.|
Zfish   372 PLACDCRLLWVFRRRWRLNF-----NRQQPSCETPEFLQGKE 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	15/58 (26%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	49/185 (26%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	16/58 (28%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	14/58 (24%)
		LRR_4	350..390	CDD:289563	10/40 (25%)
		leucine-rich repeat	351..374	CDD:275380	6/23 (26%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	9/44 (20%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	18/43 (42%)
lingo1b	NP_001004576.1	LRRNT	43..77	CDD:214470	10/36 (28%)
		LRR 1	74..95		6/20 (30%)
		leucine-rich repeat	75..98	CDD:275380	6/22 (27%)
		LRR_8	76..133	CDD:290566	15/56 (27%)
		LRR_RI	78..>315	CDD:238064	60/237 (25%)
		LRR 2	98..119		4/20 (20%)
		leucine-rich repeat	99..146	CDD:275380	13/46 (28%)
		LRR 3	122..143		7/20 (35%)
		LRR_8	130..181	CDD:290566	18/50 (36%)
		LRR 4	146..167		9/20 (45%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		LRR_8	170..226	CDD:290566	12/55 (22%)
		LRR 5	170..191		3/20 (15%)
		leucine-rich repeat	171..194	CDD:275380	3/22 (14%)
		LRR 6	194..215		5/20 (25%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		leucine-rich repeat	243..290	CDD:275380	12/47 (26%)
		LRR_8	266..325	CDD:290566	12/58 (21%)
		LRR 8	266..287		5/20 (25%)
		LRR 9	290..311		3/20 (15%)
		leucine-rich repeat	291..338	CDD:275380	11/46 (24%)
		LRR_8	314..373	CDD:290566	20/82 (24%)
		LRR 10	314..335		5/20 (25%)
		LRR 11	338..359		7/44 (16%)
		leucine-rich repeat	339..362	CDD:275380	8/46 (17%)
		TPKR_C2	371..424	CDD:301599	18/43 (42%)
		IG_like	438..516	CDD:214653
		Ig	441..516	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960