DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and MstProx

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	160/759 - (21%)
Similarity:	250/759 - (32%)	Gaps:	306/759 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PIQSLDEFRQ-------RY-----LLPLISSDTRNCSLNACESLGIVSQLLMLINSMPNGTQSAA 83
            ||:::|..||       |:     ...:|..|..  .:|..:||.|:.|..:.:|.:........
  Fly    87 PIRAVDYLRQLGVETVTRFENQINSFKVIERDVH--YINGPKSLKIIIQSNLYLNEIIEYINKTT 149

  Fly    84 NDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKRVRQI---------ESRLRSVEQPVWHLA 139
            :               :||...|||...:.|       :||         :|.|||:      ..
  Fly   150 D---------------NVNEIIINAYKTVEN-------QQIALDNLIFNGKSHLRSL------TF 186

  Fly   140 TGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGL 204
            .|.|||                       ||.:.|..|.       |:|.|.:|:..   |.|.|
  Fly   187 IGFQIE-----------------------NLSTKPFAQF-------INLKRMVLTNC---TVRNL 218

  Fly   205 TVLK---------ELDISHNVLDFLPFDL--FQDLDSLLVLRIQNNQLEDIDHRTFWKL----RN 254
            |.|:         ||||.:.|      ||  |.:..||..::::|.    |.::.|..|    :|
  Fly   219 TFLRTLQKSLEHLELDIDNEV------DLKYFTNFSSLKFMKVRNY----IPNKNFTALICTHKN 273

  Fly   255 LNIL-------------------DLSKN----EIGML---PESI-FYHAQRLTVINMCDNQIQNF 292
            .|.:                   ||..|    .:|:|   |..| .|...:|   |..:|.:...
  Fly   274 CNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKL---NFSNNSLSQL 335

  Fly   293 PPNLLRDQLMLEELDMSRNKISELSSGSIRYL-TKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSL 356
            |...|....:::.||:|||:::.|   ||.:| .||..||..:|:|..:.:|.   ::.|||:
  Fly   336 PTMTLPGYKLVKRLDVSRNRLTNL---SINHLPAKLDYLDVSFNEIINMGNDV---IKYLRTV-- 392

  Fly   357 HNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVE--------------------LNNLNE 401
                      .||....|..|:        |.|....:.                    |::|.|
  Fly   393 ----------PIFKQTGNQWTI--------HCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTE 439

  Fly   402 L------FLGQ----------------------------NSMSSIPADLFLNVSALTRLTLFSNN 432
            |      |||:                            |::::| ..::..:..|.|..:|.|.
  Fly   440 LPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTI-MSIYKYMEWLHRKLIFVNR 503

  Fly   433 LTTLEADDF-------------------------------------------------QGLNNLK 448
                |.|.|                                                 |.:::..
  Fly   504 ----EYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPM 564

  Fly   449 ILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGL-KNLVAVKLDKNPWHCDCRAL 512
            .|.|:.|.:.|... |..| .:|..|.:..|.|:.|....|..| ||.:..||..|||:|||::.
  Fly   565 ELHLSKNNISNITI-AMLP-KELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSR 627

  Fly   513 YLARWIREFVLKLWDGQQPMCR-GPGDLGGHEVGLLRYDDL--------CDGQ-WASMLSLSPRL 567
            .:...:|:.....:|.....|. .|.|.  .:|.:...|:|        |.|: ...|.|||.|
  Fly   628 SVLSILRDHEPLEYDVTLKRCNISPTDC--PDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSR- 689

  Fly   568 PVRKHQISTPMNYTDYFNLYLKHIYNGTTDEELKEADITSVSIK 611
                      :.|.|..|      .|.|...:...:.|.:.|:|
  Fly   690 ----------VTYVDLRN------NNLTALSQKNRSSIENRSLK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/69 (29%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	56/227 (25%)
		leucine-rich repeat	207..230	CDD:275380	9/33 (27%)
		leucine-rich repeat	231..254	CDD:275380	5/26 (19%)
		LRR_8	253..313	CDD:290566	20/86 (23%)
		leucine-rich repeat	255..278	CDD:275380	9/49 (18%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	19/58 (33%)
		leucine-rich repeat	303..326	CDD:275380	9/23 (39%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	16/111 (14%)
		LRR_4	350..390	CDD:289563	8/39 (21%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	4/42 (10%)
		LRR_8	398..>443	CDD:290566	15/127 (12%)
		leucine-rich repeat	399..422	CDD:275380	8/56 (14%)
		leucine-rich repeat	423..443	CDD:275380	7/68 (10%)
		leucine-rich repeat	471..494	CDD:275380	7/23 (30%)
		LRRCT	503..554	CDD:214507	14/59 (24%)
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/22 (23%)
		leucine-rich repeat	346..367	CDD:275378	9/23 (39%)
		leucine-rich repeat	563..583	CDD:275378	6/21 (29%)
		leucine-rich repeat	585..610	CDD:275378	8/24 (33%)
		leucine-rich repeat	611..622	CDD:275378	5/10 (50%)
		TIR	823..960	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840