DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LRRD1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001155000.1	Gene:	LRRD1 / 401387	HGNCID:	34300	Length:	860	Species:	Homo sapiens

Alignment Length:	573	Identity:	144/573 - (25%)
Similarity:	241/573 - (42%)	Gaps:	125/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DKKPPKSKANGHNDGDVNGGEI-----NAMSHL-ANFDLVKRVRQIE-------------SRLRS 130
            ||...|: ..|.:.||:.|.||     |.:|.| :...|:..:|.:.             |:|.:
Human   172 DKNQIKT-FQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGN 235

  Fly   131 VEQPVWHLATGSQIEWNHCTSGVCRCN--------------PDT----KSFTCWN---TNLKSVP 174
            :.|..::   .:.|| |..:...|..|              |||    |:....|   ..|.:.|
Human   236 IRQLFFY---NNYIE-NFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP 296

  Fly   175 VTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNN 239
            ........::::||:.|::|:|.|: .|.|..|:.|.:.||.|.||..::|| |..:..|::.:|
Human   297 KALCFLPKLISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADN 359

  Fly   240 QLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLE 304
            :||.|.|: ....|.|.||.|.||.:..:||.|...|. |..:::.||::... |..:.....|.
Human   360 KLEVISHK-IENFRELRILILDKNLLKNIPEKISCCAM-LECLSLSDNKLTEL-PKYIHKLNNLR 421

  Fly   305 ELDMSRNKISELSSGSIRYLTKLKTLDFGWN-------------QIAKIDDDF---------FAG 347
            :|.::||.:.:::. .|.:|..:.:|:|..|             :|.||:..:         ...
Human   422 KLHVNRNNMVKITD-CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485

  Fly   348 LRSLRTLSLHNNRISSLSGTI-FNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSS 411
            |.||..||::.|.||.:...| |:.  .|:.|:|:.|::. |....|..|.||..|.||:|.:..
Human   486 LDSLYYLSVNGNYISEIPVDISFSK--QLLHLELSENKLL-IFSEHFCSLINLKYLDLGKNQIKK 547

  Fly   412 IPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRI 476
            |||.: .|:.:|..|.|..|...|... :...|.||::|.|:.|.|:...:.... |..::||..
Human   548 IPASI-SNMISLHVLILCCNKFETFPR-ELCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNF 609

  Fly   477 DSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGG 541
            .||:.:..|            ::|      |..::|      .:..:....|:: :.|.||:|
Human   610 SSNQFIHFP------------IEL------CQLQSL------EQLNISQIKGRK-LTRLPGEL-- 647

  Fly   542 HEVGLLRYDDLCDGQWASMLSLSPRLPVRKHQI-STPMNYTDYFNLYLKHIYN 593
                            ::|..|. .|.:..:.| ..|.|..:..||...|.||
Human   648 ----------------SNMTQLK-ELDISNNAIREIPRNIGELRNLVSLHAYN 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	8/18 (44%)
		LRR_RI	<201..386	CDD:238064	59/207 (29%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	19/59 (32%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	18/79 (23%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/44 (16%)
		LRR_8	349..407	CDD:290566	21/58 (36%)
		LRR_4	350..390	CDD:289563	14/40 (35%)
		leucine-rich repeat	351..374	CDD:275380	8/23 (35%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	7/50 (14%)
LRRD1	NP_001155000.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103
		LRR 1	139..163
		leucine-rich repeat	145..165	CDD:275380
		LRR 2	164..186		4/14 (29%)
		LRR_8	166..223	CDD:290566	14/51 (27%)
		leucine-rich repeat	166..189	CDD:275380	6/17 (35%)
		LRR 3	187..210		6/22 (27%)
		leucine-rich repeat	190..212	CDD:275380	6/21 (29%)
		LRR 4	211..233		2/21 (10%)
		leucine-rich repeat	213..235	CDD:275380	3/21 (14%)
		LRR 5	235..256		4/24 (17%)
		leucine-rich repeat	236..258	CDD:275380	5/25 (20%)
		LRR 6	257..279		4/21 (19%)
		LRR_8	258..315	CDD:290566	11/56 (20%)
		leucine-rich repeat	259..281	CDD:275380	3/21 (14%)
		LRR_RI	262..501	CDD:238064	65/244 (27%)
		LRR 7	281..302		3/20 (15%)
		leucine-rich repeat	282..304	CDD:275380	3/21 (14%)
		LRR 8	303..325		7/22 (32%)
		leucine-rich repeat	305..327	CDD:275380	8/22 (36%)
		LRR_8	326..384	CDD:290566	23/59 (39%)
		LRR 9	326..348		9/22 (41%)
		leucine-rich repeat	328..350	CDD:275380	10/22 (45%)
		LRR 10	350..371		6/21 (29%)
		LRR 11	372..394		10/21 (48%)
		LRR 12	396..417		4/22 (18%)
		leucine-rich repeat	397..419	CDD:275380	4/22 (18%)
		LRR 13	419..440		5/21 (24%)
		leucine-rich repeat	420..465	CDD:275380	9/45 (20%)
		LRR 14	441..463		3/21 (14%)
		LRR 15	465..486		3/20 (15%)
		LRR 16	487..510		9/22 (41%)
		LRR_8	488..545	CDD:290566	22/59 (37%)
		leucine-rich repeat	489..511	CDD:275380	8/23 (35%)
		leucine-rich repeat	512..534	CDD:275380	7/22 (32%)
		LRR 17	512..532		6/20 (30%)
		LRR 18	533..555		9/22 (41%)
		leucine-rich repeat	535..557	CDD:275380	9/22 (41%)
		LRR_8	557..614	CDD:290566	17/58 (29%)
		LRR 19	557..578		5/21 (24%)
		leucine-rich repeat	558..580	CDD:275380	6/22 (27%)
		LRR 20	579..601		6/22 (27%)
		LRR_RI	<581..>715	CDD:238064	30/148 (20%)
		leucine-rich repeat	581..603	CDD:275380	6/22 (27%)
		LRR 21	603..624		7/38 (18%)
		leucine-rich repeat	604..626	CDD:275380	7/39 (18%)
		leucine-rich repeat	627..652	CDD:275380	7/49 (14%)
		LRR 22	627..650		6/47 (13%)
		LRR_8	651..709	CDD:290566	10/34 (29%)
		LRR 23	651..673		5/22 (23%)
		leucine-rich repeat	653..675	CDD:275380	5/22 (23%)
		LRR 24	675..696		5/9 (56%)
		leucine-rich repeat	676..698	CDD:275380	4/8 (50%)
		LRR 25	697..719
		LRR 26	721..742
		leucine-rich repeat	722..742	CDD:275380
		LRR 27	856..860
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910