DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and CG4950

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	89/324 - (27%)
Similarity:	157/324 - (48%)	Gaps:	20/324 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 NLKSVPVTQVIPMN-MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLL 232
            ||.|:..:..|..| ::.:|||.|.:|:|..:.|.||..:.::.::.|:|..|..|:|:|.:.|.
  Fly   129 NLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLE 193

  Fly   233 VLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLL 297
            .:..:.|.|..|....|..:|.:..::||.|.:..:....|..|..|..:.:..|:::||.   |
  Fly   194 KVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQ---L 255

  Fly   298 RDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRIS 362
            .::.::.:|.:..|.::.|:..:.|::..      ..|||:::   |......:.||.|..|::|
  Fly   256 TEKNIVHQLHLDNNYLTNLTINATRFVRA------SHNQISEL---FLHQSLHIETLDLSANKLS 311

  Fly   363 SLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLT 427
            |:|.  ..|:.:::.||::.|.|..::.:.|.:|..|..|.|....:..:...:|.....|..|.
  Fly   312 SISN--ITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELD 374

  Fly   428 LFSNNLTTLEADDF-QGLNNLKILLLNNNILKNFDA-RAF-EPLSQLEKLRIDSNKL--MFLPH 486
            |..||||.|..|.| ..|.|||..|::.|.|..... |.| |...||:||.:..|:.  .:|.|
  Fly   375 LSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHH 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/59 (31%)
		leucine-rich repeat	187..206	CDD:275380	9/18 (50%)
		LRR_RI	<201..386	CDD:238064	44/184 (24%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	13/59 (22%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	12/57 (21%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	14/45 (31%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	10/20 (50%)
		leucine-rich repeat	471..494	CDD:275380	6/18 (33%)
		LRRCT	503..554	CDD:214507
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380
		LRR_8	118..178	CDD:290566	15/48 (31%)
		leucine-rich repeat	120..143	CDD:275380	4/13 (31%)
		leucine-rich repeat	144..167	CDD:275380	9/22 (41%)
		leucine-rich repeat	168..191	CDD:275380	6/22 (27%)
		LRR_8	192..250	CDD:290566	13/57 (23%)
		leucine-rich repeat	192..215	CDD:275380	5/22 (23%)
		LRR_RI	<207..432	CDD:238064	63/238 (26%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	13/70 (19%)
		LRR_8	299..356	CDD:290566	17/58 (29%)
		leucine-rich repeat	300..321	CDD:275380	8/22 (36%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	344..405	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..365	CDD:275380	3/18 (17%)
		leucine-rich repeat	370..394	CDD:275380	11/23 (48%)
		leucine-rich repeat	395..420	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910