DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LHCGR

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_000224.2	Gene:	LHCGR / 3973	HGNCID:	6585	Length:	699	Species:	Homo sapiens

Alignment Length:	570	Identity:	104/570 - (18%)
Similarity:	172/570 - (30%)	Gaps:	240/570 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 NHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELD 211
            |....|..||...|...|  ..:|..:|| :|||                 ...||||..:.:::
Human    35 NCVPDGALRCPGPTAGLT--RLSLAYLPV-KVIP-----------------SQAFRGLNEVIKIE 79

  Fly   212 ISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLN-ILDLSKNEIGMLPESIFYH 275
            ||                       |.:.||.|:...|..|.||: ||..:...:..:....|.:
Human    80 IS-----------------------QIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFIN 121

  Fly   276 AQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKI 340
            ..||..:::|:..|:.||.                             :||
Human   122 LPRLKYLSICNTGIRKFPD-----------------------------VTK-------------- 143

  Fly   341 DDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTN-RISHIDGNAFVELNNLNELFL 404
                                       :|::.:|.: |::..| .|:.|.||||..:||
Human   144 ---------------------------VFSSESNFI-LEICDNLHITTIPGNAFQGMNN------ 174

  Fly   405 GQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLS 469
                            .::| |.|:.|....:::..|.|.....:.|..|..|:.....||...:
Human   175 ----------------ESVT-LKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGAT 222

  Fly   470 QLEKLRIDSNKLMFLPHGALHGLKNLVAV------KLDKN-------------PWHC-------- 507
            ..:.|.|.|.||..||...|..::.|:|.      ||...             |.||
Human   223 GPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPT 287

  Fly   508 ---------------DC---------RALYLARWIREFVLKLWD-------GQQPMCRGPGDLGG 541
                           .|         :.|| :..:.|..|..||       .:.|.|....|...
Human   288 KEQNFSHSISENFSKQCESTVRKVNNKTLY-SSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFN 351

  Fly   542 HEVGLLRYDDLCDGQW-ASMLSLSPRLPV------RKHQISTP------MNYTDY-FNLYLKHI- 591
            ....::.||.|....| .::|::...:.|      .:::::.|      :::.|: ..|||..|
Human   352 PCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIA 416

  Fly   592 ----------YNGTTD-----------------EELKEADITSVSIKKVH 614
                      ||...|                 .||....:|.:::::.|
Human   417 SVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWH 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	7/58 (12%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	29/186 (16%)
		leucine-rich repeat	207..230	CDD:275380	2/22 (9%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	11/60 (18%)
		leucine-rich repeat	255..278	CDD:275380	4/23 (17%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	2/57 (4%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..350	CDD:275380	0/22 (0%)
		LRR_8	349..407	CDD:290566	12/58 (21%)
		LRR_4	350..390	CDD:289563	6/40 (15%)
		leucine-rich repeat	351..374	CDD:275380	1/22 (5%)
		leucine-rich repeat	375..398	CDD:275380	8/23 (35%)
		LRR_8	398..>443	CDD:290566	6/44 (14%)
		leucine-rich repeat	399..422	CDD:275380	0/22 (0%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	16/102 (16%)
LHCGR	NP_000224.2	leucine-rich repeat	51..74	CDD:275380	11/42 (26%)
		LRR_5	62..198	CDD:290045	46/269 (17%)
		leucine-rich repeat	75..99	CDD:275380	8/46 (17%)
		LRR 1	96..115		5/18 (28%)
		leucine-rich repeat	100..124	CDD:275380	4/23 (17%)
		LRR 2	124..145		8/90 (9%)
		leucine-rich repeat	125..150	CDD:275380	8/94 (9%)
		LRR 3	149..171		9/22 (41%)
		leucine-rich repeat	151..174	CDD:275380	8/23 (35%)
		leucine-rich repeat	175..198	CDD:275380	6/23 (26%)
		LRR 4	175..196		5/21 (24%)
		LRR 5	198..220		5/21 (24%)
		leucine-rich repeat	199..223	CDD:275380	5/23 (22%)
		LRR 6	223..244		8/20 (40%)
		leucine-rich repeat	224..244	CDD:275380	8/19 (42%)
		7tm_1	376..623	CDD:278431	14/91 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910