DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Flrt1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_958813.1	Gene:	Flrt1 / 396184	MGIID:	3026647	Length:	674	Species:	Mus musculus

Alignment Length:	444	Identity:	111/444 - (25%)
Similarity:	174/444 - (39%)	Gaps:	100/444 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 IEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLK 208
            |:...|.| ||||  |.....|.:..|.|:|  ..||
Mouse    49 IDSTTCPS-VCRC--DNGFIYCNDRGLTSIP--SDIP---------------------------- 80

  Fly   209 ELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF 273
                                |....|.:||||           :.|..|....|.::
Mouse    81 --------------------DDATTLYLQNNQ-----------INNAGIPQDLKTKV-------- 106

  Fly   274 YHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIA 338
                ::.||.:.:|.:..||.||.|.   |.||.:..|.:..::..|:..:..|:.|....|.::
Mouse   107 ----KVQVIYLYENDLDEFPINLPRS---LRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVS 164

  Fly   339 --KIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNE 401
              .|::|.||..:.|:.|.|..|.:||:...:.:.|..   |.|..||||.|..:||..||:|..
Mouse   165 TVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEE---LRLDDNRISTIPLHAFKGLNSLRR 226

  Fly   402 LFLGQNSMSS--IPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN----NLKILLLNNNILKNF 460
            |.|..|.:::  |..|.|..:..||.|:|..|:|..      ..||    :|:.|.|.:|.:.:.
Mouse   227 LVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA------PPLNLPSAHLQKLYLQDNAISHI 285

  Fly   461 DARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKL 525
            .......:.:||:|.:.:|.|..||.|....|.||..:.|..|||.|.|..::|..|:|.....:
Mouse   286 PYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAAVV 350

  Fly   526 WDGQQPMCRGPGDLGGHEVGLLRYD-DLC--DGQWASMLSLSPRLPVRKHQIST 576
             :.:..||:||..:.|..:..:..: |.|  .|......:.:.:..|..|..:|
Mouse   351 -NVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGGAANAAAKTTVSNHASAT 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	5/58 (9%)
		leucine-rich repeat	187..206	CDD:275380	0/18 (0%)
		LRR_RI	<201..386	CDD:238064	40/186 (22%)
		leucine-rich repeat	207..230	CDD:275380	0/22 (0%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	2/22 (9%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	303..361	CDD:290566	16/59 (27%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	7/24 (29%)
		LRR_8	349..407	CDD:290566	21/57 (37%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	10/22 (45%)
		LRR_8	398..>443	CDD:290566	13/46 (28%)
		leucine-rich repeat	399..422	CDD:275380	7/24 (29%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	9/22 (41%)
		LRRCT	503..554	CDD:214507	15/53 (28%)
Flrt1	NP_958813.1	PRK15370	<58..>329	CDD:185268	88/357 (25%)
		leucine-rich repeat	108..128	CDD:275380	7/19 (37%)
		leucine-rich repeat	129..152	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..178	CDD:275380	7/24 (29%)
		leucine-rich repeat	179..199	CDD:275380	6/19 (32%)
		leucine-rich repeat	200..223	CDD:275380	11/25 (44%)
		leucine-rich repeat	224..249	CDD:275380	7/24 (29%)
		leucine-rich repeat	250..271	CDD:275380	8/26 (31%)
		leucine-rich repeat	272..295	CDD:275380	4/22 (18%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		PCC	300..>406	CDD:188093	28/105 (27%)
		FN3	441..505	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910