DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and ltl

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	136/570 - (23%)
Similarity:	214/570 - (37%)	Gaps:	178/570 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTC-----WN------TNLKSVPVTQVIPM 181
            :.|:...|:|||           |..|...|:....||     ||      ..|:|.........
  Fly     1 MTSLVYTVFHLA-----------SLQCSVRPEISPCTCETGKAWNHVELSCEKLESFNAVVDSLA 54

  Fly   182 NMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLD-SLLVLRIQNNQLEDID 245
            |.:|.|  .||                :|.|:|:.||.|....|.|:: :|..||:|.|.|:.:.
  Fly    55 NKLNAD--TNI----------------DLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLP 101

  Fly   246 HRTFWKLRNLNILDLSKNEIGMLPESIFYH------------------------AQRLTVINMCD 286
            ...|..|.|:..|.:..|::..:|:....|                        .||:|.:.:..
  Fly   102 EVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVS 166

  Fly   287 NQIQ-----NFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDF-- 344
            |.|.     :||.:||       .|.:.||::..| :||:..|..|::|....|.|..:||:.
  Fly   167 NIITRLDRGSFPKSLL-------ILHLGRNQLESL-NGSLHDLHNLESLFINANNITSLDDELPD 223

  Fly   345 --------------------FAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHID 389
                                .||:.||.|:.:|.|::.|.. .:..|..||..:....|.:.::.
  Fly   224 GGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFD-RVLRNAVNLSEVMADNNELEYLA 287

  Fly   390 GNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDF-----QGLNNLKI 449
            .:.|...:.:..|.:|.|.:.|      ||.|.|..|.|.:.|.:..:.::|     .||.:||.
  Fly   288 QDEFASCSKVETLQMGCNHIKS------LNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKT 346

  Fly   450 LLLNNNILKNF--DARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRAL 512
            |.|::|.::..  |.|..:.| .|..|.:|:|::..| :|||.||.||              |.|
  Fly   347 LQLSSNRIQRLLPDPRGVQEL-MLVNLDLDNNRIDSL-NGALAGLGNL--------------RIL 395

  Fly   513 YLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYD--DLCDGQWASM----LSLSPRLPVRK 571
            .||            |.:......||..    |::|.|  ||...|.|.:    ::|.|.|.:
  Fly   396 NLA------------GNRLEHLQVGDFD----GMIRLDILDLTGNQLAELKPLEMTLLPSLKI-- 442

  Fly   572 HQISTPMNYTDYFNLYLKHIYNGTTDEE--------LKEADITSVSIKKV 613
                            ||..||..|..|        |.:|::|:..|..:
  Fly   443 ----------------LKVAYNNITKLEQDFKGLPVLCQANLTNNQISTI 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/59 (31%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	55/236 (23%)
		leucine-rich repeat	207..230	CDD:275380	8/23 (35%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	17/88 (19%)
		leucine-rich repeat	255..278	CDD:275380	4/46 (9%)
		leucine-rich repeat	279..302	CDD:275380	7/27 (26%)
		LRR_8	303..361	CDD:290566	20/79 (25%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	8/44 (18%)
		LRR_8	349..407	CDD:290566	13/57 (23%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	3/22 (14%)
		LRR_8	398..>443	CDD:290566	12/49 (24%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	5/24 (21%)
		leucine-rich repeat	471..494	CDD:275380	10/22 (45%)
		LRRCT	503..554	CDD:214507	12/52 (23%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	8/20 (40%)
		LRR_8	86..145	CDD:290566	13/58 (22%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	0/22 (0%)
		LRR_8	158..214	CDD:290566	18/63 (29%)
		leucine-rich repeat	159..180	CDD:275380	5/20 (25%)
		leucine-rich repeat	181..203	CDD:275380	9/29 (31%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		LRR_RI	226..451	CDD:238064	68/281 (24%)
		leucine-rich repeat	227..249	CDD:275380	2/21 (10%)
		leucine-rich repeat	250..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	3/22 (14%)
		leucine-rich repeat	297..315	CDD:275380	7/23 (30%)
		LRR_8	319..402	CDD:290566	30/110 (27%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	7/21 (33%)
		leucine-rich repeat	367..391	CDD:275380	11/25 (44%)
		LRR_8	369..426	CDD:290566	24/87 (28%)
		leucine-rich repeat	392..415	CDD:275380	9/52 (17%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		LRR_8	438..>479	CDD:290566	12/57 (21%)
		leucine-rich repeat	440..462	CDD:275380	7/39 (18%)
		leucine-rich repeat	463..483	CDD:275380	4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010