DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Con

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	132/540 - (24%)
Similarity:	194/540 - (35%)	Gaps:	155/540 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVSLVL----LMDPAEVITGPSQAKEPPIQSLDEFRQRYLLPLISSDTRNCSLNACESLGIVSQL 68
            |:||:|    |:.|.|     .:||       |:.|.|               ....|.|::|..
  Fly    22 LLSLLLIGACLVTPTE-----GRAK-------DDRRTR---------------GRGSSSGVLSSS 59

  Fly    69 LMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKRVRQIESRLRSVEQ 133
            ....|:|.||..|.::......|.....:...||.|.......:.:.....|.|.::.
  Fly    60 SSSSNNMNNGYYSGSSSTAGSSSGYVFTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKL------- 117

  Fly   134 PVWHLATGSQIEWNHCTSGVCRCNPD-----TKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNIL 193
                               :|.|.||     .:...||                         :.
  Fly   118 -------------------MCYCTPDENHVPVQKAECW-------------------------VF 138

  Fly   194 ST-LHK-DT----FRGLTVLKELD--ISHNV-LDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTF 249
            |. ||: ||    |.....|:||.  |.:|. ||::|..:.:.|.:|..:.|:.:|:|.:....|
  Fly   139 SEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAF 203

  Fly   250 WKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKIS 314
            ..|..|..:.|:.|.|..|.:..|.:..||..:|:..|||........|:..:.|.|.::.|.||
  Fly   204 ANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNIS 268

  Fly   315 ELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLD 379
            .|..|                        .||.:..|..|:|.:|:|:.|:..||..|.||..|.
  Fly   269 TLHEG------------------------LFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLK 309

  Fly   380 LTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGL 444
            ||.|.::.|....|.||.:|:||.|..|.:..|      :..||                  .||
  Fly   310 LTRNNLNFIGDTVFAELWSLSELELDDNRIERI------SERAL------------------DGL 350

  Fly   445 NNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHG-LKNLV----AVKLDKNP 504
            |.||.|.|.||:||..|.........|..:.:.:|||..|....... :.|||    .:.:..|.
  Fly   351 NTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNK 415

  Fly   505 WHCDCRALYLARWIREFVLK 524
            :.||||    .:||  |.||
  Fly   416 FICDCR----LQWI--FELK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/67 (25%)
		leucine-rich repeat	187..206	CDD:275380	6/24 (25%)
		LRR_RI	<201..386	CDD:238064	53/187 (28%)
		leucine-rich repeat	207..230	CDD:275380	9/25 (36%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	13/57 (23%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	23/57 (40%)
		LRR_4	350..390	CDD:289563	16/39 (41%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	8/44 (18%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	1/19 (5%)
		leucine-rich repeat	471..494	CDD:275380	5/23 (22%)
		LRRCT	503..554	CDD:214507	10/22 (45%)
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	43/167 (26%)
		LRR_8	183..243	CDD:290566	16/59 (27%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	65/238 (27%)
		LRR_8	232..291	CDD:290566	20/82 (24%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	9/46 (20%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	27/82 (33%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
		leucine-rich repeat	329..352	CDD:275380	10/46 (22%)
		LRR_8	352..416	CDD:290566	18/63 (29%)
		leucine-rich repeat	353..376	CDD:275380	9/22 (41%)
		LRRCT	414..>450	CDD:214507	10/22 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930