DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Toll-7

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	465	Identity:	118/465 - (25%)
Similarity:	217/465 - (46%)	Gaps:	27/465 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NCSL-----NACESLGIVSQLLMLINSM---PNGTQSAANDKKPPKSKANGHNDGDVNGGEINA- 108
            :|.|     ||.|.|..:..|.:..::.   |..|.....|......:....:.||.|..::.:
  Fly   143 SCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSG 207

  Fly   109 -MSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKS 172
             :..:.|..::...|   :|:|:.||..:       .:.| |.:|......:.:.....:..|:|
  Fly   208 FLCPVGNLQVLNLTR---NRIRTAEQMGF-------ADMN-CGAGSGSAGSELQVLDASHNELRS 261

  Fly   173 VPVTQVIP--MNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLR 235
            :..:..|.  ..:.:::|:.|.||.|..:...||..|:.:::|:|.|:.||..||.....|..:.
  Fly   262 ISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIH 326

  Fly   236 IQNNQLEDIDHRTFWKLRNLNILDLSKNEI--GMLPESIFYHAQRLTVINMCDNQIQNFPPNLLR 298
            :|.|:|.::....|.:|..|.::|||.|::  ..:..:.|....||.|:|:..|.:........:
  Fly   327 LQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFK 391

  Fly   299 DQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISS 363
            :...|:.|::..|.|..:...:...|..|.||:...|::..:||..|.||..|..|:|:||.||.
  Fly   392 ELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISV 456

  Fly   364 LSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTL 428
            :...:|.|.::|..|||::|:::.:. .|..:|..|..|.||:|.:.:.....|.|:..||.|.|
  Fly   457 VEPAVFKNCSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRL 520

  Fly   429 FSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLK 493
            ..|.:..:....||.|..|.:|.|..|.:::.:..:|:...:||.:|:|.|.|..: :|....|.
  Fly   521 IDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADI-NGVFATLV 584

  Fly   494 NLVAVKLDKN 503
            :|:.:.|.:|
  Fly   585 SLLWLNLSEN 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/58 (31%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	55/186 (30%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	14/61 (23%)
		leucine-rich repeat	255..278	CDD:275380	6/24 (25%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	19/57 (33%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	1/1 (100%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	12/57 (21%)
		leucine-rich repeat	136..159	CDD:275380	6/15 (40%)
		leucine-rich repeat	160..190	CDD:275380	4/29 (14%)
		LRR_8	189..259	CDD:290566	12/80 (15%)
		leucine-rich repeat	191..214	CDD:275380	3/22 (14%)
		leucine-rich repeat	215..248	CDD:275380	8/43 (19%)
		LRR_RI	247..501	CDD:238064	70/254 (28%)
		LRR_8	247..308	CDD:290566	13/60 (22%)
		leucine-rich repeat	249..273	CDD:275380	3/23 (13%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	19/58 (33%)
		leucine-rich repeat	298..321	CDD:275380	8/22 (36%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	14/60 (23%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	23/58 (40%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	38/131 (29%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	19/57 (33%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	3/9 (33%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40411
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010