DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and lbk

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	166/737 - (22%)
Similarity:	283/737 - (38%)	Gaps:	208/737 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SSDTR---NCSLNACESLGIVSQLL----MLINSMPNGTQSAANDKKPPKSKANG-HNDGDVNGG 104
            :|::|   ||:.:.......:::||    ||:.:.....||||  :.|..|..|| ...|...|.
  Fly    65 ASESRSNDNCNYSTTNDFNKINKLLLITYMLLITAATICQSAA--QSPSSSNGNGVGGSGSTGGS 127

  Fly   105 EINAM--SHLANFDLVKRVRQI------------------------------------------- 124
            .::|:  |..|:::.....:|:
  Fly   128 PLSALLKSGGASYNQQLPQQQLFAMLTRNGGGSSGPRSSGGNRGYTSARQHFMALSEDYSDADVD 192

  Fly   125 ESRLRSVEQPVWHLATGSQIEWNHCTSGV------------------------------------ 153
            |..:.::..|:......:.::.:..:||:
  Fly   193 EEDMAALHYPLSASHPPAGVQGSSSSSGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKA 257

  Fly   154 -----CRCNPDTKS----FTCWNTNLKSVPV-----------------TQVIP----MNMVNIDL 188
                 ..|..|.|.    |.|...:|:.|||                 |.|:.    :|:..:.|
  Fly   258 SNKYNIDCPKDCKCLNVLFDCDKLHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSL 322

  Fly   189 SRNILSTLHK----------------------DTFRGLTVLKELDISHNVLDFLPFDLFQDLDSL 231
            .||:|..:.|                      ::...|.:|:.||:|.|.|..:..:.|...::|
  Fly   323 KRNLLEVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNL 387

  Fly   232 LVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQ-NFP-- 293
            :.|.:..|::.:::..:|..|.||..|:||.|.:..||..:|.:..:|..:.:..||:: |:.
  Fly   388 VHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLEINWSTF 452

  Fly   294 ------PNL---------LRDQLM-----LEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIA 338
                  .||         |:|.:.     :|.:|::.|:||.||...:..||||:.|:..:|.|:
  Fly   453 RGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAIS 517

  Fly   339 KIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELF 403
            :|:.|.:...:||..|.|.||.|:.......:.|..|.||:|..||:.::..|.|..:.||.||.
  Fly   518 RIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELN 582

  Fly   404 LGQNSMSSIPADL-----FLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDAR 463
            |.:|.:|.|..|.     |..:..|.||.|..|||..:......|||||:||.|.:|.|.:....
  Fly   583 LRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVN 647

  Fly   464 AFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDG 528
            |||.:.:|       |||:|         |:|..:        |||..::..:|::....:  ..
  Fly   648 AFEHMLRL-------NKLVF---------KSLNFI--------CDCDLVWFQQWLKNRFPQ--QA 686

  Fly   529 QQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTDYFNLYLKHIYN 593
            :..:|..|..|....:..|...:|     ..:.|..||:    .|....|...:..|:.|:.|.:
  Fly   687 EHAVCGYPEHLLDRHLKSLSSSEL-----VCVDSPKPRV----EQEPDDMLAVNAANITLECIAS 742

  Fly   594 GTTDEELKEADITSVSIKKVHN 615
            ..|...|..||  .:.||..|:
  Fly   743 SPTAASLAAAD--ELKIKWRHD 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/80 (21%)
		leucine-rich repeat	187..206	CDD:275380	6/40 (15%)
		LRR_RI	<201..386	CDD:238064	60/207 (29%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	20/82 (24%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	8/40 (20%)
		LRR_8	303..361	CDD:290566	22/57 (39%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	21/57 (37%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	17/49 (35%)
		leucine-rich repeat	399..422	CDD:275380	9/27 (33%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	9/50 (18%)
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	39/170 (23%)
		leucine-rich repeat	293..316	CDD:275380	2/22 (9%)
		LRR_8	316..373	CDD:290566	12/56 (21%)
		leucine-rich repeat	317..338	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..362	CDD:275380	1/22 (5%)
		leucine-rich repeat	363..386	CDD:275380	7/22 (32%)
		LRR_8	386..445	CDD:290566	16/58 (28%)
		leucine-rich repeat	387..410	CDD:275380	5/22 (23%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	4/21 (19%)
		LRR_8	457..516	CDD:290566	17/58 (29%)
		leucine-rich repeat	458..481	CDD:275380	4/22 (18%)
		leucine-rich repeat	482..505	CDD:275380	8/22 (36%)
		LRR_RI	<498..669	CDD:238064	63/194 (32%)
		LRR_8	504..564	CDD:290566	21/59 (36%)
		leucine-rich repeat	506..529	CDD:275380	6/22 (27%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	8/22 (36%)
		LRR_8	576..641	CDD:290566	26/64 (41%)
		leucine-rich repeat	578..604	CDD:275380	9/25 (36%)
		leucine-rich repeat	607..630	CDD:275380	9/22 (41%)
		leucine-rich repeat	631..652	CDD:275380	9/20 (45%)
		LRRCT	665..712	CDD:214507	9/61 (15%)
		IG	734..823	CDD:214652	10/31 (32%)
		Ig	735..823	CDD:143165	9/30 (30%)
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940