DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LRRTM1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	430	Identity:	108/430 - (25%)
Similarity:	174/430 - (40%)	Gaps:	88/430 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 VCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVL 217
            :|||  :.:...|...||...|...   ..::.:.|..|.||.|....|.||..|..|.:.||.:
Human    42 LCRC--EGRLLYCEALNLTEAPHNL---SGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHI 101

  Fly   218 DFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVI 282
            ..:..|.||.|..:..|.:.:||:..:.:.||..:.||..:|||.|::..|...:|:..::||.:
Human   102 CSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTL 166

  Fly   283 NMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAG 347
            :|..|.||..|..:.:|                        ...||.||.|:||:..:..:.|||
Human   167 HMRANAIQFVPVRIFQD------------------------CRSLKFLDIGYNQLKSLARNSFAG 207

  Fly   348 LRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            |..|..|.|.:|                   ||.....:|     |..|.:|:.|.|.:|.::.:
Human   208 LFKLTELHLEHN-------------------DLVKVNFAH-----FPRLISLHSLCLRRNKVAIV 248

  Fly   413 PADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRID 477
                   ||:|                  ..:.||:.:.|:.|.::..:...||.:..|:.|::|
Human   249 -------VSSL------------------DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLD 288

  Fly   478 SNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGH 542
            ||:|.::....|:..|:|.::.|..|.|.|......||.|:..|..: :||.. .|..|....|
Human   289 SNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGR-YDGNL-QCASPEYAQG- 350

  Fly   543 EVGLLRYDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTD 582
                   :|:.|..:|..|......|...|.:|...|.:|
Human   351 -------EDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSD 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/58 (31%)
		leucine-rich repeat	187..206	CDD:275380	8/18 (44%)
		LRR_RI	<201..386	CDD:238064	49/184 (27%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..350	CDD:275380	11/22 (50%)
		LRR_8	349..407	CDD:290566	12/57 (21%)
		LRR_4	350..390	CDD:289563	7/39 (18%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	7/44 (16%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	1/19 (5%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	13/50 (26%)
LRRTM1	NP_849161.2	LRR 1	64..87		6/25 (24%)
		LRR_8	73..125	CDD:290566	17/51 (33%)
		LRR_RI	<85..268	CDD:238064	63/255 (25%)
		LRR 2	89..111		6/21 (29%)
		leucine-rich repeat	91..114	CDD:275380	8/22 (36%)
		LRR 3	112..135		6/22 (27%)
		LRR_8	113..173	CDD:290566	17/59 (29%)
		leucine-rich repeat	115..138	CDD:275380	5/22 (23%)
		LRR 4	137..159		8/21 (38%)
		leucine-rich repeat	139..162	CDD:275380	7/22 (32%)
		LRR_8	161..221	CDD:290566	23/102 (23%)
		LRR 5	161..183		7/21 (33%)
		leucine-rich repeat	163..186	CDD:275380	8/46 (17%)
		LRR 6	184..207		8/22 (36%)
		leucine-rich repeat	187..210	CDD:275380	11/22 (50%)
		LRR 7	209..231		8/45 (18%)
		leucine-rich repeat	211..234	CDD:275380	9/46 (20%)
		LRR 8	233..255		7/46 (15%)
		leucine-rich repeat	235..257	CDD:275380	7/46 (15%)
		LRR 9	256..278		5/21 (24%)
		LRR_8	257..315	CDD:290566	16/57 (28%)
		LRR_4	257..297	CDD:289563	12/39 (31%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR 10	279..302		7/22 (32%)
		leucine-rich repeat	282..300	CDD:275380	6/17 (35%)
		leucine-rich repeat	306..318	CDD:275378	4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910