DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7509 and Lgr6

DIOPT Version :9

Sequence 1:NP_647931.1 Gene:CG7509 / 38579 FlyBaseID:FBgn0035575 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_001028581.1 Gene:Lgr6 / 329252 MGIID:2441805 Length:967 Species:Mus musculus


Alignment Length:421 Identity:115/421 - (27%)
Similarity:164/421 - (38%) Gaps:77/421 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 CRCNPD--TKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNV 216
            |.|..|  ..|..|....|..|| ..:.|:. ..:|||.|.|:.|....|..|..|:||.:|.|.
Mouse    39 CHCQEDGIMLSADCSELGLSVVP-ADLDPLT-AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH 101

  Fly   217 LDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTV 281
            |..:|...|..|.||.:|.:|:|||..|.....|:|.:|..|.|..|.|.::||..|.....|..
Mouse   102 LSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166

  Fly   282 INMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFA 346
            :.:.||.:...|...|.:...|:.:.::.|.|..:...:.:.||.|..|....|:|..:....|.
Mouse   167 LWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFE 231

  Fly   347 GLRSLRTLSL-----------------------HNNRISSLSGTIFNNLANLVTLDLTTNRISHI 388
            ||.:|.||.|                       |||.|.::....|.....|.|:....|.|..:
Mouse   232 GLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFV 296

  Fly   389 DGNAFVELNNLNELFL-GQNSMSSIPADL----FLNVSALTR----------------------- 425
            ..:||..|:.|:.|.| |...:...| ||    .|.:..|||                       
Mouse   297 GRSAFQYLSKLHTLSLNGATDIQEFP-DLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELS 360

  Fly   426 ------------------LTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLE 472
                              :.|..|.:..:.||.|..|.:|:.|.|:.|.::.....||..|..|.
Mouse   361 HNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLV 425

  Fly   473 KLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            ||.:..|:|..||   |.||..|:.:||..|
Mouse   426 KLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7509NP_647931.1 LRR_8 182..241 CDD:290566 22/58 (38%)
leucine-rich repeat 187..206 CDD:275380 8/18 (44%)
LRR_RI <201..386 CDD:238064 58/207 (28%)
leucine-rich repeat 207..230 CDD:275380 9/22 (41%)
leucine-rich repeat 231..254 CDD:275380 9/22 (41%)
LRR_8 253..313 CDD:290566 15/59 (25%)
leucine-rich repeat 255..278 CDD:275380 8/22 (36%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR_8 303..361 CDD:290566 19/80 (24%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR_8 349..407 CDD:290566 20/81 (25%)
LRR_4 350..390 CDD:289563 13/62 (21%)
leucine-rich repeat 351..374 CDD:275380 9/45 (20%)
leucine-rich repeat 375..398 CDD:275380 7/22 (32%)
LRR_8 398..>443 CDD:290566 16/90 (18%)
leucine-rich repeat 399..422 CDD:275380 8/27 (30%)
leucine-rich repeat 423..443 CDD:275380 8/60 (13%)
leucine-rich repeat 471..494 CDD:275380 10/22 (45%)
LRRCT 503..554 CDD:214507 1/1 (100%)
Lgr6NP_001028581.1 LRRNT 34..68 CDD:214470 9/29 (31%)
LRR_4 70..107 CDD:289563 14/36 (39%)
leucine-rich repeat 70..91 CDD:275380 8/20 (40%)
LRR 1 91..112 8/20 (40%)
LRR_8 92..150 CDD:290566 23/57 (40%)
LRR_4 92..131 CDD:289563 17/38 (45%)
leucine-rich repeat 92..115 CDD:275380 9/22 (41%)
LRR 2 115..136 8/20 (40%)
leucine-rich repeat 116..139 CDD:275380 9/22 (41%)
LRR_8 138..198 CDD:290566 15/59 (25%)
LRR 3 139..160 8/20 (40%)
leucine-rich repeat 140..163 CDD:275380 8/22 (36%)
LRR_RI 143..392 CDD:238064 53/249 (21%)
LRR 4 163..186 5/22 (23%)
leucine-rich repeat 164..187 CDD:275380 5/22 (23%)
LRR_8 186..246 CDD:290566 16/59 (27%)
LRR 5 187..208 3/20 (15%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
LRR 6 211..232 5/20 (25%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
LRR 7 235..256 4/20 (20%)
leucine-rich repeat 236..258 CDD:275380 4/21 (19%)
LRR_8 258..314 CDD:290566 15/55 (27%)
LRR 8 258..279 5/20 (25%)
leucine-rich repeat 259..282 CDD:275380 5/22 (23%)
LRR 9 282..302 5/19 (26%)
leucine-rich repeat 283..304 CDD:275380 6/20 (30%)
LRR 10 303..325 7/22 (32%)
LRR_8 305..364 CDD:290566 11/59 (19%)
leucine-rich repeat 307..348 CDD:275380 11/41 (27%)
LRR 11 329..350 4/20 (20%)
LRR 12 353..374 0/20 (0%)
leucine-rich repeat 354..375 CDD:275380 0/20 (0%)
LRR_8 375..434 CDD:290566 17/58 (29%)
LRR 13 375..396 5/20 (25%)
leucine-rich repeat 376..399 CDD:275380 6/22 (27%)
LRR 14 399..420 6/20 (30%)
leucine-rich repeat 400..421 CDD:275380 6/20 (30%)
LRR 15 423..443 9/22 (41%)
leucine-rich repeat 424..444 CDD:275380 10/22 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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