DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP001706

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_551097.3	Gene:	AgaP_AGAP001706 / 3290509	VectorBaseID:	AGAP001706	Length:	548	Species:	Anopheles gambiae

Alignment Length:	435	Identity:	109/435 - (25%)
Similarity:	163/435 - (37%)	Gaps:	127/435 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 RCNPDTKSFTCWNT-NLKSVPVTQVIPMNMVNIDLSRN-------ILSTLHKDTFRGLTVLKELD 211
            |.:|:...|...:| ||:         .|...:||||.       .||::..|.:.    :.||:
Mosquito    14 RHSPNWDGFLTEDTLNLR---------QNETEVDLSRQGFKEVHWHLSSIVGDGYE----IFELN 65

  Fly   212 ISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF--- 273
            ::.|.|:.|....|....||..|.:.||:|:.|.:.||..|..|..||||.|.|..|....|
Mosquito    66 LAFNNLEELNELTFLKFYSLETLNLSNNRLQTISNLTFGSLIRLVELDLSFNLIHTLERQAFDRL 130

  Fly   274 YHAQRLTVINMC---------------------DNQIQNFPPNLLRDQLMLE---ELDMSRNKIS 314
            |..:.|::...|                     .||:...||.|.....|::   |||:|.|
Mosquito   131 YALESLSLRENCLVTLAPNQFHFNDHLSSVLLDHNQLAFLPPILFDPITMVDEIYELDLSDN--- 192

  Fly   315 ELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLR-----SLRTLSLHNNRISSLSGTIF----- 369
                 :.|.:..::|.:..   :.|||::....|.     ::|.|.:.:|.|  ....:|
Mosquito   193 -----NFRRMPYIETKEIA---LLKIDNNHIETLTVNKSFNVRALQIQHNNI--YDADLFKFNRA 247

  Fly   370 -------NNLANLV---------TLDLTTNRISHIDGNAFVELNNLNELF--------LGQNSMS 410
                   |||.|:|         .|||::|.:|..|.|....:.|:..|.        |.::::.
Mosquito   248 EHIDLSHNNLDNIVGLHEMNQLEYLDLSSNNVSKFDYNLKYSIRNIPSLVTLRLQNCSLSEHNIG 312

  Fly   411 SIPA-DLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKL 474
            .:.| |..||      |.|..||...|...|...:.:|:.|.||.|.|:.        |...|:|
Mosquito   313 GLLASDSILN------LDLSQNNFVRLNVSDLSRMRSLQYLSLNFNYLRE--------LISYERL 363

  Fly   475 RIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHC---DCRALYLAR 516
            .              |....|..|.|..|.|:|   |....||.|
Mosquito   364 G--------------HEFPFLELVSLSFNRWNCTYYDQLNAYLNR 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/65 (29%)
		leucine-rich repeat	187..206	CDD:275380	7/25 (28%)
		LRR_RI	<201..386	CDD:238064	59/237 (25%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	23/86 (27%)
		leucine-rich repeat	255..278	CDD:275380	10/25 (40%)
		leucine-rich repeat	279..302	CDD:275380	7/43 (16%)
		LRR_8	303..361	CDD:290566	14/65 (22%)
		leucine-rich repeat	303..326	CDD:275380	6/25 (24%)
		leucine-rich repeat	327..350	CDD:275380	5/27 (19%)
		LRR_8	349..407	CDD:290566	20/91 (22%)
		LRR_4	350..390	CDD:289563	15/60 (25%)
		leucine-rich repeat	351..374	CDD:275380	8/34 (24%)
		leucine-rich repeat	375..398	CDD:275380	8/31 (26%)
		LRR_8	398..>443	CDD:290566	13/53 (25%)
		leucine-rich repeat	399..422	CDD:275380	6/31 (19%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	3/22 (14%)
		LRRCT	503..554	CDD:214507	7/17 (41%)
AgaP_AGAP001706	XP_551097.3	leucine-rich repeat	63..84	CDD:275380	6/20 (30%)
		LRR_8	84..141	CDD:290566	21/56 (38%)
		LRR_4	84..123	CDD:289563	17/38 (45%)
		leucine-rich repeat	85..108	CDD:275380	9/22 (41%)
		leucine-rich repeat	109..132	CDD:275380	9/22 (41%)
		LRR_RI	111..356	CDD:238064	64/263 (24%)
		leucine-rich repeat	133..156	CDD:275380	2/22 (9%)
		leucine-rich repeat	157..183	CDD:275380	6/25 (24%)
		leucine-rich repeat	184..225	CDD:275380	11/51 (22%)
		LRR_8	225..279	CDD:290566	14/55 (25%)
		leucine-rich repeat	226..247	CDD:275380	5/22 (23%)
		leucine-rich repeat	248..268	CDD:275380	5/19 (26%)
		leucine-rich repeat	269..295	CDD:275380	8/25 (32%)
		leucine-rich repeat	296..314	CDD:275380	2/17 (12%)
		leucine-rich repeat	320..343	CDD:275380	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910