DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP007467

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_564790.3	Gene:	AgaP_AGAP007467 / 3290377	VectorBaseID:	AGAP007467	Length:	406	Species:	Anopheles gambiae

Alignment Length:	344	Identity:	72/344 - (20%)
Similarity:	140/344 - (40%)	Gaps:	58/344 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SFTCWNTNLKSVPVTQVI-PMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLF 225
            |:..:...:..:|....: .:.:||..:.|::::    .|.|.||   .|.:.:.:||.:|..|.
Mosquito    51 SYMAYKDPVFQLPADNTLTEIEIVNAVMLRSLVA----GTNRHLT---RLYVENCLLDRIPPTLS 108

  Fly   226 Q--DLDSLLVLR----------IQNNQLEDIDHRTFWKLRNLNILDLSKNEIGML------PESI 272
            .  :|:.||:::          :.||.             .|..:||::|.|..|      |::
Mosquito   109 NMIELEELLIMQCALTALRLDVLVNNP-------------KLTTIDLTRNRIRQLFPITTPPKT- 159

  Fly   273 FYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQI 337
               ...:|.:.:..||::....::......||:.|:..|:|....:........|..|....|.|
Mosquito   160 ---KLAVTFLGLAANQLERLDMSMFAFMPELEQFDVRGNRIVRFEATVPVIYGSLMRLLVSSNNI 221

  Fly   338 AKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNEL 402
            .:.|..... |..||:|.|.:|.::.|. |.:..|..|:.|....|.:..:|.:.|.:...|..:
Mosquito   222 TQFDTRNLT-LSELRSLYLDDNALTELP-THWGKLPKLIYLGFDRNYLKRVDMSFFGKFPTLTAI 284

  Fly   403 FLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN--NLKILLLNNNILKNFDARAF 465
            |:.:|.:.:|.....:.:..|..:...||.:.::   :|.|.|  .:.::.|.||.|     ...
Mosquito   285 FISENIVETIRTSTPITMPELDIILFESNQIVSV---NFTGCNFPKMNLVSLTNNRL-----TTI 341

  Fly   466 EPLSQL---EKLRIDSNKL 481
            .||.|.   .:|.::.|.:
Mosquito   342 PPLLQRFSESRLTMEGNPI 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/70 (24%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	45/202 (22%)
		leucine-rich repeat	207..230	CDD:275380	6/24 (25%)
		leucine-rich repeat	231..254	CDD:275380	4/32 (13%)
		LRR_8	253..313	CDD:290566	14/65 (22%)
		leucine-rich repeat	255..278	CDD:275380	7/28 (25%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	15/57 (26%)
		LRR_4	350..390	CDD:289563	11/39 (28%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	8/44 (18%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	2/14 (14%)
		LRRCT	503..554	CDD:214507
AgaP_AGAP007467	XP_564790.3	LRR_8	88..147	CDD:290566	17/74 (23%)
		leucine-rich repeat	90..112	CDD:275380	7/24 (29%)
		leucine-rich repeat	113..136	CDD:275380	5/35 (14%)
		LRR_8	135..197	CDD:290566	14/78 (18%)
		leucine-rich repeat	137..160	CDD:275380	7/26 (27%)
		leucine-rich repeat	161..186	CDD:275380	3/24 (13%)
		leucine-rich repeat	187..210	CDD:275380	5/22 (23%)
		leucine-rich repeat	211..233	CDD:275380	6/22 (27%)
		LRR_8	232..289	CDD:290566	15/57 (26%)
		leucine-rich repeat	234..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..327	CDD:275380	6/24 (25%)
		leucine-rich repeat	328..351	CDD:275380	7/27 (26%)
		leucine-rich repeat	352..370	CDD:275380	2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910