DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and TOLL5A

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_560220.3	Gene:	TOLL5A / 3289806	VectorBaseID:	AGAP000999	Length:	1057	Species:	Anopheles gambiae

Alignment Length:	490	Identity:	123/490 - (25%)
Similarity:	203/490 - (41%)	Gaps:	125/490 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 VPVTQVIPM------------------NMVNIDL------SRNILSTLHKDTFRGLTVLKELDIS 213
            :|..||:.|                  ::..|||      |||....||.     ||.|..|:::
Mosquito   136 LPALQVLSMKNSSRMPLDNPELFKYLQSLTWIDLREGDGGSRNSKVLLHT-----LTQLTTLELT 195

  Fly   214 HNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQR 278
            .|.|..||.:|..||.||..|.:.:|:||.|:.  |..|.||..|||:.||:..|.|.:||....
Mosquito   196 ENELTTLPTELITDLPSLGSLTLYHNKLERIEQ--FADLPNLTSLDLTYNELDTLQEDVFYKLPN 258

  Fly   279 LTVINMCDNQIQNFPPNLLR---------------------DQL-----MLEELDMSRNKISELS 317
            ||.:.:..|::.:.|..||:                     |:|     |||::.:|..|::.|.
Mosquito   259 LTHLFLNSNKLTSLPSGLLKRNTKLIVFRADNQHGSGLVLGDELFAGLTMLEDVSVSNCKLTTLP 323

  Fly   318 SGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSL-HNNRISSLSGTIFNNLANLVTLDLT 381
            .|.....:||..||...|::..:.::.......|:.|.| ||..|:.|..|:..:...|..|:|.
Mosquito   324 EGLFTAASKLTKLDVSDNKLQSLPENLLRHSSILKELYLQHNELINMLPDTLLQSTNKLRILNLG 388

  Fly   382 TNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNN-------------- 432
            .|:::.:........|:|.||.|..|.:..|..|.|::.:...::...|:|
Mosquito   389 HNKLTTLSKYLLDSKNSLEELHLEYNQLYMIDRDAFISQAQSLKMLNLSHNQVALHVNGTDVFYL 453

  Fly   433 -----------------LTTLEAD---------DFQG-LNNLKILLLNNNILKNFDARAFEPLS- 469
                             ||.|:..         ||:| :.||:.|.|::|::.|...:.|..||
Mosquito   454 DGKTYYISQTPFYILAQLTDLDLSYNAIIKIFGDFKGFMGNLQSLDLSHNLIMNISDKDFSFLSP 518

  Fly   470 QLEKLRIDSNKL-MFLPHGAL------HGLKNLVAVKLDKNPWHCDCRALYLARWIRE------F 521
            ::||:.::||:: ||..:.:.      ..:.....:.|..|..:|||.:..|..::::      |
Mosquito   519 KIEKVNLESNRITMFTFNDSKKSTFSNRSINTPRQILLADNSLNCDCISSSLVTYLQDQLNAGKF 583

  Fly   522 VLKLWDGQQPM----CRGPGDLGGHEVGLLRYDDL 552
            |        |:    |..|.:|.|.:...|..:||
Mosquito   584 V--------PLKGLHCAQPPELLGRKPQDLSLEDL 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	23/64 (36%)
		leucine-rich repeat	187..206	CDD:275380	8/24 (33%)
		LRR_RI	<201..386	CDD:238064	63/211 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	23/85 (27%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	8/48 (17%)
		LRR_8	303..361	CDD:290566	16/58 (28%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	17/58 (29%)
		LRR_4	350..390	CDD:289563	12/40 (30%)
		leucine-rich repeat	351..374	CDD:275380	8/23 (35%)
		leucine-rich repeat	375..398	CDD:275380	4/22 (18%)
		LRR_8	398..>443	CDD:290566	15/84 (18%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	7/59 (12%)
		leucine-rich repeat	471..494	CDD:275380	6/29 (21%)
		LRRCT	503..554	CDD:214507	15/60 (25%)
TOLL5A	XP_560220.3	leucine-rich repeat	98..121	CDD:275380
		leucine-rich repeat	139..163	CDD:275380	3/23 (13%)
		LRR_8	211..269	CDD:290566	23/59 (39%)
		LRR_4	211..250	CDD:289563	17/40 (43%)
		leucine-rich repeat	213..234	CDD:275380	8/22 (36%)
		LRR_4	233..274	CDD:289563	14/40 (35%)
		leucine-rich repeat	235..258	CDD:275380	10/22 (45%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		leucine-rich repeat	283..308	CDD:275380	2/24 (8%)
		LRR_RI	300..531	CDD:238064	56/230 (24%)
		LRR_8	309..367	CDD:290566	16/57 (28%)
		leucine-rich repeat	309..332	CDD:275380	6/22 (27%)
		leucine-rich repeat	333..356	CDD:275380	4/22 (18%)
		LRR_8	357..416	CDD:290566	18/58 (31%)
		leucine-rich repeat	357..381	CDD:275380	8/23 (35%)
		leucine-rich repeat	382..405	CDD:275380	4/22 (18%)
		leucine-rich repeat	406..424	CDD:275380	7/17 (41%)
		leucine-rich repeat	431..470	CDD:275380	2/38 (5%)
		LRR_8	470..530	CDD:290566	19/59 (32%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		leucine-rich repeat	495..516	CDD:275380	6/20 (30%)
		leucine-rich repeat	589..705	CDD:275380	7/22 (32%)
		leucine-rich repeat	706..731	CDD:275380
		TIR	843..981	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910