DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lgi1a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_955921.2	Gene:	lgi1a / 323011	ZFINID:	ZDB-GENE-030131-1731	Length:	537	Species:	Danio rerio

Alignment Length:	402	Identity:	87/402 - (21%)
Similarity:	160/402 - (39%)	Gaps:	72/402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFR 202
            |..|.:...:.|.: .|.|:.|  :..|.||.  ::|  :..|.:::::...::..:.:.|::|.
Zfish    17 LVLGGRRRSSRCPA-PCTCSKD--NALCANTG--AIP--RSFPQDVISLSFVKSGFTEIPKESFI 74

  Fly   203 GLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGM 267
            ....|..|..:.|..|.:..|.|..|..|..|.|:|||::.|....|..|::|..|.|:.|.:..
Zfish    75 HTPALHLLLFTANSFDSINEDAFLGLPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLET 139

  Fly   268 LPESIFYHAQRLTVINM------CDNQIQ-----NFPPNLLRDQLMLEELD-MSRNKISELSSGS 320
            ||:.:|...:.||.:::      ||.:::     .|..|...||:.....: ....||::|.:.:
Zfish   140 LPKDLFKGMEALTKVDLRGNLFSCDCKLKWLVDWMFHTNATVDQIFCNGPEGYQGKKINDLEAQT 204

  Fly   321 IRYLTK----LKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLS----GTIFNNLANLVT 377
            ...:|.    ||:|:|   |...::...|||.:.:......:.|.|.:.    ...|.|..|:.:
Zfish   205 FDCITTDFTLLKSLEF---QSISVEAFSFAGDQFVVFAQPFSGRCSFMEWDHVQMEFRNFDNITS 266

  Fly   378 LDLTTNRISHIDGNAFVELNNLNELFLGQNSMS-SIPADLFLNVSALTRLTLFSNNLTTLEADDF 441
            ......:...||...|:   .:.:||.|.:... .:.|:.|:.:
Zfish   267 TSTVICKPLVIDSQLFI---IVAQLFGGSHIFKRDVSANKFIRI--------------------- 307

  Fly   442 QGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDS----NKLMFLPHGALHGLKNLVAVKLDK 502
            |.::.|||...|:..:...|..:|..::...|....:    |...|..:.:||
Zfish   308 QDIDILKIRKPNDVEIFEVDGESFFIIADSSKAGSTTIYKWNGNGFYSYQSLH------------ 360

  Fly   503 NPWHCDCRALYL 514
             |||.|....||
Zfish   361 -PWHRDTDVEYL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	14/58 (24%)
		leucine-rich repeat	187..206	CDD:275380	2/18 (11%)
		LRR_RI	<201..386	CDD:238064	49/204 (24%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	15/71 (21%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	8/33 (24%)
		LRR_8	303..361	CDD:290566	12/62 (19%)
		leucine-rich repeat	303..326	CDD:275380	3/23 (13%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	11/61 (18%)
		LRR_4	350..390	CDD:289563	6/43 (14%)
		leucine-rich repeat	351..374	CDD:275380	4/26 (15%)
		leucine-rich repeat	375..398	CDD:275380	3/22 (14%)
		LRR_8	398..>443	CDD:290566	5/45 (11%)
		leucine-rich repeat	399..422	CDD:275380	5/23 (22%)
		leucine-rich repeat	423..443	CDD:275380	0/19 (0%)
		leucine-rich repeat	471..494	CDD:275380	5/26 (19%)
		LRRCT	503..554	CDD:214507	6/12 (50%)
lgi1a	NP_955921.2	LRR_8	57..113	CDD:290566	14/55 (25%)
		LRR_4	77..120	CDD:289563	14/42 (33%)
		leucine-rich repeat	79..102	CDD:275378	7/22 (32%)
		LRR_8	101..161	CDD:290566	18/59 (31%)
		LRR_4	101..141	CDD:289563	13/39 (33%)
		leucine-rich repeat	103..126	CDD:275378	9/22 (41%)
		leucine-rich repeat	127..150	CDD:275378	7/22 (32%)
		leucine-rich repeat	151..163	CDD:275378	2/11 (18%)
		TPKR_C2	159..207	CDD:301599	9/47 (19%)
		EPTP	211..252	CDD:281697	10/43 (23%)
		EPTP	257..298	CDD:281697	9/43 (21%)
		EPTP	303..349	CDD:281697	9/66 (14%)
		EPTP	352..394	CDD:281697	9/33 (27%)
		EPTP	399..441	CDD:281697
		EPTP	444..485	CDD:281697
		EPTP	490..530	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000