DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrrc58

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_796067.2	Gene:	Lrrc58 / 320184	MGIID:	2443542	Length:	366	Species:	Mus musculus

Alignment Length:	390	Identity:	96/390 - (24%)
Similarity:	146/390 - (37%)	Gaps:	105/390 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHR 247
            ::.:.|..|.|::|.:....|...|:.||:|.|.|..|..:|. .|..|..|..:||:|
Mouse    41 LLRLLLPYNRLTSLPRALGGGFPHLQLLDVSGNSLTALGPELL-TLSGLRTLLARNNRL------ 98

  Fly   248 TFWKLRNLNILDLSKNEIGMLPESIFYH--AQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSR 310
                           ...|.||:.:...  .:.|.|:|:..|..|..|.:||.
Mouse    99 ---------------GGPGSLPKGLAQSPLCRSLQVLNLSGNCFQELPASLLE------------ 136

  Fly   311 NKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANL 375
                                                 ||:|:||||..|::.|:...| .||.:|
Mouse   137 -------------------------------------LRALQTLSLGGNQLQSIPAEI-ENLRSL 163

  Fly   376 VTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADD 440
            ..|.|..|.|..|... ...|.:||.|.|..|.:.|:|..| ..:.:|..|:| .|||.|....:
Mouse   164 ECLYLGGNFIKEIPPE-LANLPSLNYLVLCDNKIQSVPPQL-SQLHSLRSLSL-HNNLLTYLPRE 225

  Fly   441 FQGLNNLKILLLNNN--ILKNFDARAFEPLSQLE------KLRIDSNKLMFLPHGALHGLKNLVA 497
            ...|.:|:.|.|..|  :::......::|.:.||      |:|..|.....|| |.|  |:.|.:
Mouse   226 ILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRSISYTPYDLP-GNL--LRYLGS 287

  Fly   498 VKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLS 562
            .....||   .|..:|....:|:  :|..|    .|      |.:.:.|:.|  ||..:.:|..|
Mouse   288 ASNCPNP---KCGGVYFDCCVRQ--IKFVD----FC------GKYRLPLMHY--LCSPECSSPCS 335

Fly 563 562
Mouse 336 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/57 (32%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	42/186 (23%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	11/61 (18%)
		leucine-rich repeat	255..278	CDD:275380	3/24 (13%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	303..361	CDD:290566	8/57 (14%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..350	CDD:275380	1/22 (5%)
		LRR_8	349..407	CDD:290566	22/57 (39%)
		LRR_4	350..390	CDD:289563	16/39 (41%)
		leucine-rich repeat	351..374	CDD:275380	10/22 (45%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	10/28 (36%)
		LRRCT	503..554	CDD:214507	12/50 (24%)
Lrrc58	NP_796067.2	LRR 1	40..61		4/19 (21%)
		LRR_RI	<54..206	CDD:238064	54/225 (24%)
		LRR 2	64..86		8/22 (36%)
		leucine-rich repeat	65..87	CDD:275380	9/22 (41%)
		LRR 3	87..108		8/41 (20%)
		leucine-rich repeat	88..116	CDD:275380	8/48 (17%)
		LRR_8	115..171	CDD:290566	23/105 (22%)
		LRR 4	116..138		8/70 (11%)
		leucine-rich repeat	117..139	CDD:275380	9/70 (13%)
		LRR 5	139..161		9/22 (41%)
		leucine-rich repeat	140..162	CDD:275380	10/22 (45%)
		LRR_8	161..219	CDD:290566	20/60 (33%)
		LRR 6	162..184		6/22 (27%)
		leucine-rich repeat	163..185	CDD:275380	7/22 (32%)
		LRR 7	185..206		8/21 (38%)
		leucine-rich repeat	186..208	CDD:275380	8/22 (36%)
		LRR 8	208..229		7/21 (33%)
		leucine-rich repeat	209..231	CDD:275380	8/22 (36%)
		LRR 9	231..251		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910