DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrig2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	120/450 - (26%)
Similarity:	209/450 - (46%)	Gaps:	46/450 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 NPDTKS-------FTCWNTNLKSVPVTQV---------IPM------NMVNIDLSRNILSTLHKD 199
            :||..|       .:.||.:|:|..:.:|         ||.      |:..:.|..|::..::.:
  Rat    73 SPDISSLDLSHNRLSNWNISLESETLQEVKMNYNELTEIPYFGEPTPNITQLSLVHNLIPEINAE 137

  Fly   200 TFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLR-NLNILDLSKN 263
            .|:..:.|:.||:|.|::..:....|..: ||..|.:.||::..::...|..|. :|.::.|::|
  Rat   138 AFQLYSALESLDLSSNIISEIKTSSFPRM-SLKYLNLSNNRITTLEAGCFDNLSGSLLVVKLNRN 201

  Fly   264 EIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLK 328
            .|.|:|..:| ....|..:.:..|:|:.......:....|..|.|.||.||:|..|:...|..::
  Rat   202 RISMIPPKVF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNME 265

  Fly   329 TLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAF 393
            .|:...|.:..:...:..|||.|:.|.:..|.|..:|...:.....|..|||:.|:::.:|.:||
  Rat   266 ELELEHNNLTGVHKGWLYGLRMLQQLYVSQNAIEKISPDAWEFCQRLSALDLSYNQLTRLDESAF 330

  Fly   394 VELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLT-TLE--ADDFQGLNNLKILLLNNN 455
            |.|:.|..|.||.|.::.|...:|..:|.|..|.|.:|.:: .:|  ::.|.||.:|..|:|..|
  Rat   331 VGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEVFSGLKSLTKLILQGN 395

  Fly   456 ILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGAL---HGLKNLVAVKLDKNPWHCDCRALYLARW 517
            .:|:...:||..|..||.|.:::|.:|.:...|.   | ||.||   |:.:...|||...:|.:|
  Rat   396 RIKSVTQKAFVGLESLEYLDLNNNAIMSIQENAFSQTH-LKELV---LNTSSLLCDCHLKWLLQW 456

  Fly   518 IREFVLKLWDGQQPMCRGPGDLGGHEV-GLLRYDDLCDGQWASMLSLSPRLPVRKHQIST 576
            :.:  ..........|..|..|.|..: .:...|.:||.      .|.|:  :|.|..:|
  Rat   457 LVD--NNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDD------FLKPQ--IRTHPENT 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	15/58 (26%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	49/185 (26%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/23 (26%)
		LRR_8	253..313	CDD:290566	15/60 (25%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	10/22 (45%)
		LRR_8	398..>443	CDD:290566	14/47 (30%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	471..494	CDD:275380	8/25 (32%)
		LRRCT	503..554	CDD:214507	10/51 (20%)
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064	30/131 (23%)
		leucine-rich repeat	98..120	CDD:275380	3/21 (14%)
		LRR_8	119..178	CDD:290566	15/59 (25%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		LRR_RI	136..398	CDD:238064	74/263 (28%)
		leucine-rich repeat	145..167	CDD:275380	6/22 (27%)
		LRR_8	167..226	CDD:290566	16/59 (27%)
		leucine-rich repeat	168..192	CDD:275380	6/23 (26%)
		leucine-rich repeat	193..215	CDD:275380	7/22 (32%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		LRR_8	239..298	CDD:290566	18/58 (31%)
		leucine-rich repeat	240..263	CDD:275380	10/22 (45%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		LRR_8	311..370	CDD:290566	22/58 (38%)
		leucine-rich repeat	312..335	CDD:275380	10/22 (45%)
		leucine-rich repeat	336..359	CDD:275380	7/22 (32%)
		LRR_8	358..421	CDD:290566	21/62 (34%)
		leucine-rich repeat	360..384	CDD:275380	6/23 (26%)
		LRR_4	385..426	CDD:289563	13/40 (33%)
		leucine-rich repeat	387..410	CDD:275380	8/22 (36%)
		leucine-rich repeat	411..433	CDD:275380	6/21 (29%)
		LRRCT	444..492	CDD:214507	10/49 (20%)
		Ig	501..597	CDD:299845	1/5 (20%)
		IG	503..597	CDD:214652	0/3 (0%)
		I-set	601..691	CDD:254352
		Ig_1	618..692	CDD:143240
		I-set	695..782	CDD:254352
		Ig	713..782	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000