DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Nyx

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001094437.1	Gene:	Nyx / 302516	RGDID:	1561300	Length:	476	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	117/450 - (26%)
Similarity:	179/450 - (39%)	Gaps:	87/450 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTK--SFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNV 216
            |.|:...:  |..|....|:.||..  .|....:|||.||.|..|.:..|..|..|:.|.:.||.
  Rat    30 CTCSNVERGCSVRCDRAGLQRVPTE--FPCEAASIDLDRNGLRILGERAFGTLPSLRCLSLRHNN 92

  Fly   217 LDFLPFDLFQDLDSLLVLRI-QNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLT 280
            |.|:....|:.|..|..||: .|.:|..:..|||..|..|..|||:...:..:||.:......|.
  Rat    93 LSFITPGAFKGLPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAELPALR 157

  Fly   281 VINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFF 345
            .:...||..:..|                         |::|.|..|....|..::|..:.....
  Rat   158 ELTAFDNLFRRVP-------------------------GALRGLANLTHAHFERSRIEAVASSSL 197

  Fly   346 AGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMS 410
            .|:|.||:|||..||:.::....|.:...|..|.|..|.::.:...||..|..|..|.||.|::.
  Rat   198 LGMRRLRSLSLQANRVRAVHAGAFGDCVALEHLLLNDNLLASLPAAAFRGLRRLRTLNLGGNALG 262

  Fly   411 SIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLR 475
            |:....|.:::.|..|.|..|::|.:|...||.|:.|..|.||.|.|......||:|...|.:|
  Rat   263 SVARGWFSDLAELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRLTVLSWAAFQPGFFLGRL- 326

  Fly   476 IDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLG 540
                 .:|                  :|||.|||.    ..|:|:::..........|..||.:.
  Rat   327 -----FLF------------------RNPWRCDCH----LEWLRDWMEGSGRVADVACASPGSVA 364

  Fly   541 GHEVGLLRYDDLCDG---------------------------QWASMLS--LSPRLPVRK 571
            |.::..:.::...||                           :::|:||  |:||.||.:
  Rat   365 GQDLSQVVFERSSDGICVDPDELNFTTFSPGPSPEPVATTVSRFSSLLSKLLAPRAPVEE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	21/59 (36%)
		leucine-rich repeat	187..206	CDD:275380	8/18 (44%)
		LRR_RI	<201..386	CDD:238064	49/185 (26%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/23 (39%)
		LRR_8	253..313	CDD:290566	10/59 (17%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	14/44 (32%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	3/22 (14%)
		LRRCT	503..554	CDD:214507	12/50 (24%)
Nyx	NP_001094437.1	LRRNT	25..56	CDD:214470	7/27 (26%)
		leucine-rich repeat	63..82	CDD:275380	8/18 (44%)
		LRR_RI	<68..312	CDD:238064	76/268 (28%)
		LRR_8	81..142	CDD:290566	21/60 (35%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		leucine-rich repeat	107..131	CDD:275380	9/23 (39%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..178	CDD:275380	7/46 (15%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		LRR_8	201..261	CDD:290566	21/59 (36%)
		leucine-rich repeat	203..226	CDD:275380	8/22 (36%)
		leucine-rich repeat	227..250	CDD:275380	7/22 (32%)
		LRR_8	249..309	CDD:290566	21/59 (36%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		leucine-rich repeat	275..296	CDD:275380	8/20 (40%)
		leucine-rich repeat	299..318	CDD:275380	7/18 (39%)
		LRRCT	331..>366	CDD:214507	11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910