DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001099857.1	Gene:	Lrrtm3 / 294380	RGDID:	1304866	Length:	582	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	112/476 - (23%)
Similarity:	189/476 - (39%)	Gaps:	94/476 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 FDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVI 179
            |::::.:|  .|.:..|..|...|...|..| ..|..| |||  :.|...|.:..|:.:|.:
  Rat     3 FNVIRLLR--GSAVAVVLAPTVLLTMLSSAE-RGCPKG-CRC--EGKMVYCESQKLQEIPSS--- 58

  Fly   180 PMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDI 244
                    :|...|.               |.:.:|.|..|.::.|:.|:.|..|.:.:|.:.:|
  Rat    59 --------ISAGCLG---------------LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNI 100

  Fly   245 DHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMS 309
            |...|..:|.                                                |:||.:|
  Rat   101 DENAFNGIRR------------------------------------------------LKELILS 117

  Fly   310 RNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLAN 374
            .|:||...:.:.|.:|.|:.||..:||:..:..:.|.|||.|.:|.|.:|.:.::...||.:..|
  Rat   118 SNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRN 182

  Fly   375 LVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEAD 439
            |..|||..|||..:..|.|..:..|.||.|..|..|.:...||..:.:|..|.:..|.::.:...
  Rat   183 LELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQT 247

  Fly   440 DFQGLNNLKILLLNNNILKNFDA-RAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            .....::|:.|.|:.|.::.|.. ..|:.:..|::|.:|||||.|:....|....:|..:.|..|
  Rat   248 MSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312

  Fly   504 PWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGG-HEVGLLRYDDLCDGQWAS-------- 559
            .|.|......|..|::.|  |.......:|..|.:|.| :.:..::...:|.....:
  Rat   313 IWECSRNICSLVNWLKSF--KGLRENTILCASPKELQGVNVIDAVKNYSICGKSTTTERFDLARA 375

  Fly   560 --MLSLSPRLPVRKHQISTPM 578
              ..:..|:||..||:...|:
  Rat   376 LPKPTFKPKLPRPKHESKPPL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	11/58 (19%)
		leucine-rich repeat	187..206	CDD:275380	2/18 (11%)
		LRR_RI	<201..386	CDD:238064	44/184 (24%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	6/59 (10%)
		leucine-rich repeat	255..278	CDD:275380	0/22 (0%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	22/57 (39%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	21/57 (37%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	9/22 (41%)
		LRRCT	503..554	CDD:214507	11/51 (22%)
Lrrtm3	NP_001099857.1	LRRNT	33..61	CDD:214470	9/41 (22%)
		LRR 1	61..83		6/36 (17%)
		leucine-rich repeat	66..86	CDD:275380	6/19 (32%)
		LRR_RI	<81..300	CDD:238064	69/266 (26%)
		LRR 2	84..107		7/22 (32%)
		LRR_8	86..145	CDD:290566	20/106 (19%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		LRR 3	109..131		8/69 (12%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR 4	132..155		7/22 (32%)
		LRR_8	133..193	CDD:290566	22/59 (37%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	156..179		8/22 (36%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	181..241	CDD:290566	21/59 (36%)
		LRR 6	181..203		10/21 (48%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		LRR 7	205..227		8/21 (38%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	229..251		3/21 (14%)
		LRR_8	230..290	CDD:290566	14/59 (24%)
		leucine-rich repeat	231..254	CDD:275380	3/22 (14%)
		LRR 9	252..276		6/23 (26%)
		leucine-rich repeat	255..279	CDD:275380	6/23 (26%)
		LRR 10	277..300		9/22 (41%)
		leucine-rich repeat	280..300	CDD:275380	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..411		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910