DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and GP5

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_004479.1	Gene:	GP5 / 2814	HGNCID:	4443	Length:	560	Species:	Homo sapiens

Alignment Length:	440	Identity:	128/440 - (29%)
Similarity:	187/440 - (42%)	Gaps:	59/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 IPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQ--- 240
            :|.|:.:|.|.......|...:|.|:|||:.|.||.:.:..:....|.||..|..||:..|:
Human    48 LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112

  Fly   241 ---------------------LEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINM 284
                                 |..||...|.||.||..|.|::|::..||.|:|.:.:.|.::::
Human   113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDL 177

  Fly   285 CDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLR 349
            ..|.:.:.|..||..|..||.|.:..|::..|.||.:..|..|..|.|..|.|..|....|..|.
Human   178 SGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLP 242

  Fly   350 SLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPA 414
            :|.:|:|..|.::.|...:|.:..||..|.|..|.::.:.|..|.|:..|.||:|.:..:.::||
Human   243 NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPA 307

  Fly   415 DLFLNVSALTR-------------------------LTLFSNNLTTLEADDFQGLNNLKILLLNN 454
            ..|.|:|.|..                         |.|.||.||.|.....:||..|:.:.|..
Human   308 AAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRR 372

  Fly   455 NILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIR 519
            |.|:......|..||.||.:::|.|:|..||......|..|..|.|..|.|.|||.......|:|
Human   373 NRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLR 437

  Fly   520 EFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDL-CDGQWASMLSLSPRLP 568
            :.:..:...:.|.|.|||...|..:..|...|. |.|         ||.|
Human   438 QHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPG---------PRGP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/82 (23%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	63/208 (30%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	10/46 (22%)
		LRR_8	253..313	CDD:290566	19/59 (32%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	20/57 (35%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	11/39 (28%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	17/69 (25%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	8/44 (18%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	15/51 (29%)
GP5	NP_004479.1	LRR 1	75..96		6/20 (30%)
		LRR_RI	<76..230	CDD:238064	44/153 (29%)
		LRR_8	76..134	CDD:290566	11/57 (19%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR 2	99..120		4/20 (20%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		LRR 3	123..144		4/20 (20%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_8	147..206	CDD:290566	19/58 (33%)
		LRR 4	147..168		9/20 (45%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR_RI	163..400	CDD:238064	68/236 (29%)
		LRR 5	171..193		5/21 (24%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRR_8	195..254	CDD:290566	20/58 (34%)
		LRR 6	195..216		7/20 (35%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		LRR_8	242..302	CDD:290566	18/59 (31%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR 10	291..312		7/20 (35%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		LRR_8	314..375	CDD:290566	14/60 (23%)
		leucine-rich repeat	316..338	CDD:275380	1/21 (5%)
		LRR 11	340..361		7/20 (35%)
		leucine-rich repeat	341..364	CDD:275380	9/22 (41%)
		LRR_8	364..421	CDD:290566	18/56 (32%)
		LRR 12	364..385		5/20 (25%)
		leucine-rich repeat	365..388	CDD:275380	6/22 (27%)
		LRR 13	388..409		7/20 (35%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		LRRCT	421..472	CDD:214507	15/50 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..498		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4083
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40411
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.930