DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and MXRA5

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_056234.2	Gene:	MXRA5 / 25878	HGNCID:	7539	Length:	2828	Species:	Homo sapiens

Alignment Length:	292	Identity:	70/292 - (23%)
Similarity:	118/292 - (40%)	Gaps:	64/292 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 ELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIF 369
            |:..:...::.:.:|..:::.:   ::.|:|.|..:.:..||||..|..|.:|.|.|.|:.....
Human    38 EVHCTFRSLASVPAGIAKHVER---INLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGAL 99

  Fly   370 NNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLT 434
            .:|::|.....:.|::..|.|.....|:||..|.:..|.:.      |::..|
Human   100 RDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIE------FIHPQA------------ 146

  Fly   435 TLEADDFQGLNNLKILLLNNNILKNFDARAFEP--------LSQLEKLRIDSNKLMFLPHGALHG 491
                  |.||.:|::|.|..|:|.......|..        ||.:..|.:..|.:..||...|..
Human   147 ------FNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRN 205

  Fly   492 LKNLVAVKLDKNPWHCDCRALYLARWIREF------VL-----KLWDGQQ--PMCRGPGDLGGHE 543
            :..|..:.|..|||.|||.    .||..|:      :|     |.::|.|  .||..|..|..||
Human   206 MPLLENLYLQGNPWTCDCE----MRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSPKKLYKHE 266

  Fly   544 VGLLRYDDLCDGQWASMLSLSPRL--PVRKHQ 573
            :..|:          .|..|.|.:  |:|:::
Human   267 IHKLK----------DMTCLKPSIESPLRQNR 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566
		leucine-rich repeat	187..206	CDD:275380
		LRR_RI	<201..386	CDD:238064	18/80 (23%)
		leucine-rich repeat	207..230	CDD:275380
		leucine-rich repeat	231..254	CDD:275380
		LRR_8	253..313	CDD:290566	1/7 (14%)
		leucine-rich repeat	255..278	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	303..361	CDD:290566	13/55 (24%)
		leucine-rich repeat	303..326	CDD:275380	2/20 (10%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	15/57 (26%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	7/44 (16%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	1/19 (5%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	20/63 (32%)
MXRA5	NP_056234.2	leucine-rich repeat	38..55	CDD:275380	2/16 (13%)
		LRR_8	55..115	CDD:290566	16/62 (26%)
		LRR 1	56..77		4/23 (17%)
		leucine-rich repeat	57..80	CDD:275380	7/25 (28%)
		LRR 2	80..101		6/20 (30%)
		leucine-rich repeat	81..104	CDD:275380	7/22 (32%)
		LRR_8	102..163	CDD:290566	19/84 (23%)
		LRR 3	104..125		4/20 (20%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		LRR_4	128..168	CDD:289563	14/63 (22%)
		LRR 4	128..149		7/44 (16%)
		leucine-rich repeat	129..152	CDD:275380	8/46 (17%)
		LRR 5	152..173		6/20 (30%)
		leucine-rich repeat	153..184	CDD:275380	7/30 (23%)
		LRR 6	184..205		5/20 (25%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		LRRCT	217..>263	CDD:214507	16/49 (33%)
		IG	486..572	CDD:214652
		IGc2	493..558	CDD:197706
		IG	590..668	CDD:214652
		IGc2	591..658	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..715
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..962
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1275
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1367..1389
		LRR 7	1410..1434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1536..1566
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1669..1689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1700..1719
		IG_like	1860..1945	CDD:214653
		Ig	1868..1945	CDD:299845
		I-set	1958..2042	CDD:254352
		IGc2	1965..2032	CDD:197706
		I-set	2047..2139	CDD:254352
		Ig	2065..2137	CDD:299845
		IG_like	2153..2238	CDD:214653
		Ig	2161..2229	CDD:299845
		IG	2258..2341	CDD:214652
		Ig	2258..2332	CDD:299845
		IG_like	2356..2435	CDD:214653
		Ig	2361..2435	CDD:299845
		I-set	2440..2535	CDD:254352
		Ig	2459..2535	CDD:299845
		IG	2549..2633	CDD:214652
		Ig	2561..2633	CDD:299845
		IG	2652..2728	CDD:214652
		Ig	2655..2724	CDD:143165
		IG_like	2741..2827	CDD:214653
		Ig	2751..2824	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910