DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lingo2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	414	Identity:	115/414 - (27%)
Similarity:	191/414 - (46%)	Gaps:	46/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PVWH---------LATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLS 189
            |.|.         |..||.|   .|.:. |.|:...||.:|....|.::|  :.||:....:|||
Mouse     7 PCWQPFLGLAVVLLLMGSTI---GCPAR-CECSAQNKSVSCHRRRLLAIP--EGIPIETKILDLS 65

  Fly   190 RNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRN 254
            :|.|.:::.:.|....:|:|:|:|.|::..:....|.:|.:|..||::.|:|:.:....|..|.|
Mouse    66 KNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSN 130

  Fly   255 LNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSG 319
            |..||:|:|:|.:|.:.:|.....|..:.:.||.:...........|.||:|.:.:..::.:.:.
Mouse   131 LTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTE 195

  Fly   320 SIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL--ANLVTLDLTT 382
            ::.:|..|..|......|..:....|..|..|:.|.:....:..|...  |:|  .||.:|.:|.
Mouse   196 ALSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPA--NSLYGLNLTSLSITN 258

  Fly   383 NRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNL 447
            ..:|.:...||..|..|..|.|..|.:|:|.|.:|.::..|..|.:....|.|:|...||||..|
Mouse   259 TNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323

  Fly   448 KILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRAL 512
            ::|.::.|:|:..:...|.....||.|.|::                        ||..||||.|
Mouse   324 RVLNVSQNLLETLEENVFSSPRALEVLSINN------------------------NPLACDCRLL 364

  Fly   513 YLARWIREFVLKLWDGQQPMCRGP 536
            :|.:  |:..|: :.||||||.||
Mouse   365 WLLQ--RQPNLQ-FGGQQPMCAGP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/58 (29%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	46/186 (25%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	11/57 (19%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	16/59 (27%)
		LRR_4	350..390	CDD:289563	10/41 (24%)
		leucine-rich repeat	351..374	CDD:275380	5/24 (21%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	14/44 (32%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	4/22 (18%)
		LRRCT	503..554	CDD:214507	18/34 (53%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	10/35 (29%)
		leucine-rich repeat	39..57	CDD:275380	6/19 (32%)
		LRR 1	58..79		6/20 (30%)
		leucine-rich repeat	59..82	CDD:275380	6/22 (27%)
		LRR_8	60..117	CDD:404697	17/56 (30%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR_8	106..165	CDD:404697	19/58 (33%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		9/20 (45%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		3/20 (15%)
		leucine-rich repeat	155..178	CDD:275380	3/22 (14%)
		PPP1R42	176..>373	CDD:411060	58/224 (26%)
		LRR 6	178..199		3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		LRR 7	202..223		4/20 (20%)
		leucine-rich repeat	203..250	CDD:275380	10/48 (21%)
		LRR 8	226..247		4/22 (18%)
		LRR 9	250..271		7/20 (35%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		LRR 10	274..295		8/20 (40%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR 11	298..319		6/20 (30%)
		leucine-rich repeat	299..322	CDD:275380	9/22 (41%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		LRRCT	355..408	CDD:214507	18/34 (53%)
		Ig	411..500	CDD:416386
		Ig strand A'	417..421	CDD:409353
		Ig strand B	427..436	CDD:409353
		Ig strand C	441..446	CDD:409353
		Ig strand C'	449..451	CDD:409353
		Ig strand D	460..463	CDD:409353
		Ig strand E	466..473	CDD:409353
		Ig strand F	479..487	CDD:409353
		Ig strand G	490..500	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910