DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Lrrc8a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_808393.1	Gene:	Lrrc8a / 241296	MGIID:	2652847	Length:	810	Species:	Mus musculus

Alignment Length:	351	Identity:	94/351 - (26%)
Similarity:	157/351 - (44%)	Gaps:	50/351 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LKSVP--VTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHN-------VLDFLPFDL- 224
            |..:|  |..::.:.::.::|..::  |: ..:...||.||||.:.|.       .|.||..:|
Mouse   435 LSGIPDTVFDLVELEVLKLELIPDV--TI-PPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496

  Fly   225 -----FQDLDSLLV----------------LRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGML 268
                 |.|:..:.:                |..:||:...||  ...:|:.|.:|.| |:.:..|
Mouse   497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVID--GLRELKRLKVLRL-KSNLSKL 558

  Fly   269 PE---SIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTL 330
            |:   .:..|.|:|::.|.....|   ..|.|:..:.|.||::.|..:..:.. ||..|..|:.:
Mouse   559 PQVVTDVGVHLQKLSINNEGTKLI---VLNSLKKMVNLTELELIRCDLERIPH-SIFSLHNLQEI 619

  Fly   331 DFGWNQIAKIDDDF-FAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFV 394
            |...|.:..|::.. |..|..|..|.|..|.|:.:...| .||.||..|.|..|:|..|....|.
Mouse   620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI-GNLTNLERLYLNRNKIEKIPTQLFY 683

  Fly   395 ELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKN 459
             ...|..|.|..|:::.:|||:.| :..|..|.:.:|.:..|..:.|| ...|:.|.|.||:|::
Mouse   684 -CRKLRYLDLSHNNLTFLPADIGL-LQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQS 745

  Fly   460 FDARAFEPLSQLEKLRIDSNKLMFLP 485
            ..:|..| |:.|.::.:..|:|..||
Mouse   746 LPSRVGE-LTNLTQIELRGNRLECLP 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/87 (21%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	58/217 (27%)
		leucine-rich repeat	207..230	CDD:275380	11/35 (31%)
		leucine-rich repeat	231..254	CDD:275380	6/38 (16%)
		LRR_8	253..313	CDD:290566	17/62 (27%)
		leucine-rich repeat	255..278	CDD:275380	7/25 (28%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	17/58 (29%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/23 (26%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	15/39 (38%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	5/15 (33%)
		LRRCT	503..554	CDD:214507
Lrrc8a	NP_808393.1	Pannexin_like	1..340	CDD:403656
		LRR 1. /evidence=ECO:0000255	399..422
		leucine-rich repeat	420..447	CDD:275380	3/11 (27%)
		LRR 2. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	423..445		3/9 (33%)
		LRR 3. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	447..468		2/23 (9%)
		leucine-rich repeat	448..470	CDD:275380	3/24 (13%)
		LRR 4. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	469..492		8/22 (36%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRR 5. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	493..515		3/21 (14%)
		leucine-rich repeat	495..517	CDD:275380	3/21 (14%)
		LRR	<514..789	CDD:227223	76/269 (28%)
		leucine-rich repeat	518..545	CDD:275380	6/28 (21%)
		LRR 6. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	518..542		5/25 (20%)
		LRR 7. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	543..565		7/22 (32%)
		leucine-rich repeat	546..568	CDD:275380	6/22 (27%)
		LRR 8. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	567..589		7/24 (29%)
		leucine-rich repeat	569..592	CDD:275380	6/25 (24%)
		LRR 9. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	590..613		6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	614..637		5/22 (23%)
		leucine-rich repeat	616..640	CDD:275380	6/23 (26%)
		LRR 11. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	639..661		6/22 (27%)
		leucine-rich repeat	641..663	CDD:275380	8/22 (36%)
		LRR 12. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	662..684		8/22 (36%)
		leucine-rich repeat	664..686	CDD:275380	7/22 (32%)
		LRR 13. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	686..707		8/21 (38%)
		leucine-rich repeat	687..709	CDD:275380	8/22 (36%)
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:Q8IWT6	706..707		1/1 (100%)
		LRR 14. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	708..730		6/22 (27%)
		leucine-rich repeat	710..732	CDD:275380	6/22 (27%)
		LRR 15. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	732..753		8/21 (38%)
		leucine-rich repeat	733..755	CDD:275380	9/22 (41%)
		LRR 16. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	754..776		5/17 (29%)
		LRR 17. /evidence=ECO:0000255, ECO:0000305\|PubMed:29769723	778..801
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910