DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Tlr11

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_991388.2	Gene:	Tlr11 / 239081	MGIID:	3045226	Length:	931	Species:	Mus musculus

Alignment Length:	479	Identity:	105/479 - (21%)
Similarity:	168/479 - (35%)	Gaps:	152/479 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 WNTNLKSVPVTQVIPMNMVN----------IDLSRNILSTLH------------KDTFRGLTVLK 208
            :|..||...|..:..:.:.:          :||:.:.|..||            ..:..|.:.|:
Mouse   231 YNLQLKQAGVRDLYGLTLHSLILDGTPLKALDLTDSGLLHLHFLSLVGTGIEKVPASLTGYSELR 295

  Fly   209 ELDISHN-VLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIG---MLP 269
            .||:..| :.:.|.........:|..|.:.:|.|:.:..|....|..|..|:||.|::|   .||
Mouse   296 ALDLGKNQIQNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNKLGPILELP 360

  Fly   270 ESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGW 334
            |.:|  :..|.|:::..||:.:.|...|.....|:||.:|.|.||.||:.|::.|.:|:|||..|
Mouse   361 EGLF--STNLKVLDLSYNQLCDVPHGALSLLSQLQELWLSGNNISSLSNESLQGLRQLRTLDLSW 423

  Fly   335 NQIAKIDDDFFAGLRSLRTLSLHNNRISSL----------------------------------- 364
            |||..:...:.:.|.:|.||:|....:..:
Mouse   424 NQIKVLKPGWLSHLPALTTLNLLGTYLEYILGIQLQGPKMLRHLQLGSYPILDIYPPWPPTLLSL 488

  Fly   365 -------------SGTIFNNLANL-------------VTLDLTTNRISHIDGNAFV-ELNNLNEL 402
                         ||..|..|.||             :|:...:.|...:.|.:|: ..:.|...
Mouse   489 EIQAESCIQFMIHSGQPFLFLENLTLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRF 553

  Fly   403 FLGQNSM---------SSIPADLFL------------------------------NVSALTRLTL 428
            |..|..:         :|...||:|                              .|..|..|.|
Mouse   554 FPQQLPLLEHFFIWCENSYAVDLYLFGMPRLRVLELGYLNFFYESSTMKLEMLLKEVPQLQVLAL 618

  Fly   429 FSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLK 493
            ...||..|....|:.|.:||:||.|:.       ||.|         ::||...|:|....:
Mouse   619 SHLNLRNLSVSSFKSLQDLKLLLFNSE-------RALE---------MNSNLQEFIPQMPQY--- 664

  Fly   494 NLVAVKLDKNPWHCDCRALYLARW 517
                |......:.|.|.|.:|..|
Mouse   665 ----VYFSDVTFTCQCEASWLESW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	14/81 (17%)
		leucine-rich repeat	187..206	CDD:275380	6/30 (20%)
		LRR_RI	<201..386	CDD:238064	60/249 (24%)
		leucine-rich repeat	207..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	21/62 (34%)
		leucine-rich repeat	255..278	CDD:275380	10/25 (40%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	24/57 (42%)
		leucine-rich repeat	303..326	CDD:275380	11/22 (50%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	16/119 (13%)
		LRR_4	350..390	CDD:289563	12/100 (12%)
		leucine-rich repeat	351..374	CDD:275380	8/70 (11%)
		leucine-rich repeat	375..398	CDD:275380	5/36 (14%)
		LRR_8	398..>443	CDD:290566	15/83 (18%)
		leucine-rich repeat	399..422	CDD:275380	8/61 (13%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	4/22 (18%)
		LRRCT	503..554	CDD:214507	5/15 (33%)
Tlr11	NP_991388.2	LRR_RI	<184..427	CDD:238064	55/197 (28%)
		leucine-rich repeat	224..246	CDD:275380	4/14 (29%)
		leucine-rich repeat	248..270	CDD:275380	3/21 (14%)
		leucine-rich repeat	271..293	CDD:275380	3/21 (14%)
		leucine-rich repeat	294..318	CDD:275380	5/23 (22%)
		LRR_8	319..378	CDD:290566	19/60 (32%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		leucine-rich repeat	343..367	CDD:275380	10/25 (40%)
		LRR_8	366..426	CDD:290566	23/59 (39%)
		leucine-rich repeat	368..391	CDD:275380	6/22 (27%)
		leucine-rich repeat	392..415	CDD:275380	11/22 (50%)
		LRR_8	414..471	CDD:290566	13/56 (23%)
		leucine-rich repeat	416..437	CDD:275380	8/20 (40%)
		leucine-rich repeat	440..463	CDD:275380	4/22 (18%)
		TIR_2	781..>861	CDD:290400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910