DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and FLRT1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001371395.1	Gene:	FLRT1 / 23769	HGNCID:	3760	Length:	674	Species:	Homo sapiens

Alignment Length:	408	Identity:	106/408 - (25%)
Similarity:	161/408 - (39%)	Gaps:	101/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 IEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLK 208
            |:...|.| ||||  |.....|.:..|.|:|..  ||
Human    49 IDSTTCPS-VCRC--DNGFIYCNDRGLTSIPAD--IP---------------------------- 80

  Fly   209 ELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF 273
                                |....|.:||||           :.|..|....|.::
Human    81 --------------------DDATTLYLQNNQ-----------INNAGIPQDLKTKV-------- 106

  Fly   274 YHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIA 338
                .:.||.:.:|.:..||.||.|.   |.||.:..|.:..::..|:..:..|:.|....|.::
Human   107 ----NVQVIYLYENDLDEFPINLPRS---LRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVS 164

  Fly   339 --KIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNE 401
              .|::|.||..:.|:.|.|..|.:||:...:.:.|..   |.|..||||.|..:||..||:|..
Human   165 TVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEE---LRLDDNRISTIPLHAFKGLNSLRR 226

  Fly   402 LFLGQNSMSS--IPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN----NLKILLLNNNILKNF 460
            |.|..|.:::  |..|.|..:..||.|:|..|:|..      ..||    :|:.|.|.:|.:.:.
Human   227 LVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA------PPLNLPSAHLQKLYLQDNAISHI 285

  Fly   461 DARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWI--REFVL 523
            .......:.:||:|.:.:|.|..||.|....|.||..:.|..|||.|.|..::|..|:  |..|:
Human   286 PYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVV 350

  Fly   524 KLWDGQQPMCRGPGDLGG 541
            .:   :..||:||..:.|
Human   351 NV---RGLMCQGPEKVRG 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	5/58 (9%)
		leucine-rich repeat	187..206	CDD:275380	0/18 (0%)
		LRR_RI	<201..386	CDD:238064	40/186 (22%)
		leucine-rich repeat	207..230	CDD:275380	0/22 (0%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	2/22 (9%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	303..361	CDD:290566	16/59 (27%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	7/24 (29%)
		LRR_8	349..407	CDD:290566	21/57 (37%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	10/22 (45%)
		LRR_8	398..>443	CDD:290566	13/46 (28%)
		leucine-rich repeat	399..422	CDD:275380	7/24 (29%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	9/22 (41%)
		LRRCT	503..554	CDD:214507	14/41 (34%)
FLRT1	NP_001371395.1	PRK15370	<58..>329	CDD:185268	88/357 (25%)
		leucine-rich repeat	108..128	CDD:275380	7/19 (37%)
		leucine-rich repeat	129..152	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..178	CDD:275380	7/24 (29%)
		leucine-rich repeat	179..199	CDD:275380	6/19 (32%)
		leucine-rich repeat	200..223	CDD:275380	11/25 (44%)
		leucine-rich repeat	224..249	CDD:275380	7/24 (29%)
		leucine-rich repeat	250..271	CDD:275380	8/26 (31%)
		leucine-rich repeat	272..295	CDD:275380	4/22 (18%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		PCC	300..>406	CDD:188093	23/69 (33%)
		FN3	441..505	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910