DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and FLRT3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_037413.1	Gene:	FLRT3 / 23767	HGNCID:	3762	Length:	649	Species:	Homo sapiens

Alignment Length:	480	Identity:	119/480 - (24%)
Similarity:	188/480 - (39%)	Gaps:	100/480 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 CTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILST--LHKDTFRGLTVLKELD 211
            |.| ||||  |.....|.:..|.|:|..  ||.:...:.|..|.::.  :..| .:.|..::.:.
Human    31 CPS-VCRC--DAGFIYCNDRFLTSIPTG--IPEDATTLYLQNNQINNAGIPSD-LKNLLKVERIY 89

  Fly   212 ISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIG--MLPESIFY 274
            :.||.||..|.:|.:.:..   |.:|.|.:..|.:.:..|:..|..|.|..|.:.  .:.|..|.
Human    90 LYHNSLDEFPTNLPKYVKE---LHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFR 151

  Fly   275 HAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAK 339
            .:..|.::.:..|.:...|..|.|   .:|||.:..|:||.:||.|::.||.||.|
Human   152 DSNYLRLLFLSRNHLSTIPWGLPR---TIEELRLDDNRISTISSPSLQGLTSLKRL--------- 204

  Fly   340 IDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISH-IDGNAFVELNNLNELF 403
                                   .|.|.:.||               | :....|..|.||.||.
Human   205 -----------------------VLDGNLLNN---------------HGLGDKVFFNLVNLTELS 231

  Fly   404 LGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPL 468
            |.:||:::.|.:|                         .| .||:.|.|.:|.:......||..|
Human   232 LVRNSLTAAPVNL-------------------------PG-TNLRKLYLQDNHINRVPPNAFSYL 270

  Fly   469 SQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMC 533
            .||.:|.:.:|.|..||.|....|.|:..:.|..|||:|.|:..::..|::...:|: :.:..||
Human   271 RQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMC 334

  Fly   534 RGPGDLGGHEVGLLRYD--DLCDGQWASMLSLSPRLP--VRKHQISTPMNYT---DYFNLYLKHI 591
            :.|..:.|..:..|..:  |..|....|.:.::..:|  |...|...|...|   |..|..|...
Human   335 QAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKD 399

  Fly   592 YNGTTDEELKEADIT--SVSIKKVH 614
            :..|.....|...||  ||:...:|
Human   400 HQTTGSPSRKTITITVKSVTSDTIH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/60 (22%)
		leucine-rich repeat	187..206	CDD:275380	4/20 (20%)
		LRR_RI	<201..386	CDD:238064	41/186 (22%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	15/61 (25%)
		leucine-rich repeat	255..278	CDD:275380	6/24 (25%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		LRR_8	349..407	CDD:290566	12/58 (21%)
		LRR_4	350..390	CDD:289563	5/40 (13%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		leucine-rich repeat	375..398	CDD:275380	3/23 (13%)
		LRR_8	398..>443	CDD:290566	9/44 (20%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	0/19 (0%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	13/52 (25%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	13/34 (38%)
		Interaction with ADGRL3. /evidence=ECO:0000269\|PubMed:26235030	38..67		8/30 (27%)
		LRR 1. /evidence=ECO:0000255	59..80		3/21 (14%)
		leucine-rich repeat	61..84	CDD:275378	4/23 (17%)
		LRR 2. /evidence=ECO:0000255	84..104		6/19 (32%)
		leucine-rich repeat	85..104	CDD:275380	6/18 (33%)
		LRR 3. /evidence=ECO:0000255	105..126		4/23 (17%)
		LRR_8	106..166	CDD:290566	13/62 (21%)
		leucine-rich repeat	106..129	CDD:275380	5/25 (20%)
		LRR_RI	<120..259	CDD:238064	48/214 (22%)
		LRR 4. /evidence=ECO:0000255	129..150		5/20 (25%)
		leucine-rich repeat	130..155	CDD:275380	6/24 (25%)
		LRR 5. /evidence=ECO:0000255	155..175		4/19 (21%)
		leucine-rich repeat	156..176	CDD:275380	5/22 (23%)
		LRR_8	175..237	CDD:290566	28/111 (25%)
		LRR 6. /evidence=ECO:0000255	176..197		9/20 (45%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		LRR 7. /evidence=ECO:0000255	200..220		8/66 (12%)
		leucine-rich repeat	201..226	CDD:275380	10/71 (14%)
		LRR 8. /evidence=ECO:0000255	226..247		10/46 (22%)
		leucine-rich repeat	227..248	CDD:275380	9/46 (20%)
		LRR_8	247..306	CDD:290566	19/58 (33%)
		LRR_4	247..287	CDD:289563	13/39 (33%)
		LRR 9. /evidence=ECO:0000255	248..269		7/20 (35%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	272..293		8/20 (40%)
		leucine-rich repeat	273..296	CDD:275380	8/22 (36%)
		LRRCT	305..356	CDD:214507	13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		4/19 (21%)
		fn3	413..478	CDD:278470	5/12 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910