DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lingo3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	394	Identity:	112/394 - (28%)
Similarity:	179/394 - (45%)	Gaps:	41/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |.|:..|::..|....|.::|  :.||.....::||||.:..|:......|..|:|||::|||:.
Mouse    28 CECSASTRTVACGRRRLTAIP--EGIPAETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIA 90

  Fly   219 FLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVIN 283
            .:....|.:|..|.|||::.|||:.|....|..|.:|.:||||:|::.:|.:..|...:.|..:.
Mouse    91 HVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLE 155

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGL 348
            :.||.:...........|.|.||.:.|..::.||..|:.:|..|..|......||.::|..|..|
Mouse   156 VGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKL 220

  Fly   349 RSLRTLSLHNNRI------SSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQN 407
            ..|..|.:.|..:      .||.|      .||.:|.:|...|:.:...|..:..:|..|.|..|
Mouse   221 PGLSHLEIDNWPLLEEVAPGSLRG------LNLTSLSITHTNITAVPAAALRQQAHLTCLNLSHN 279

  Fly   408 SMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLE 472
            .:|.:|...|.::..|..|.|....|..:|...|.||..:::|.|::|:|...:...|..::.||
Mouse   280 PISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNLLSTLEENTFHSVNTLE 344

  Fly   473 KLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPG 537
            .||:|.                        ||..||||.|::.:  |...|. :||:.|.|..|.
Mouse   345 TLRVDG------------------------NPLACDCRLLWIVQ--RRKTLN-FDGRLPACATPA 382

  Fly   538 DLGG 541
            ::.|
Mouse   383 EVRG 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	57/190 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	10/22 (45%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	15/63 (24%)
		LRR_4	350..390	CDD:289563	11/45 (24%)
		leucine-rich repeat	351..374	CDD:275380	6/28 (21%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	15/39 (38%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	8/28 (29%)
		leucine-rich repeat	34..53	CDD:275380	5/20 (25%)
		LRR 1	54..75		5/20 (25%)
		LRR	<55..353	CDD:227223	90/327 (28%)
		leucine-rich repeat	55..78	CDD:275380	6/22 (27%)
		LRR 2	78..99		8/20 (40%)
		leucine-rich repeat	79..102	CDD:275380	9/22 (41%)
		LRR 3	102..123		9/20 (45%)
		leucine-rich repeat	103..150	CDD:275380	18/46 (39%)
		LRR 4	126..147		8/20 (40%)
		LRR 5	150..171		3/20 (15%)
		leucine-rich repeat	151..174	CDD:275380	3/22 (14%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR 7	206..227		6/20 (30%)
		leucine-rich repeat	223..246	CDD:275380	6/28 (21%)
		LRR_8	246..302	CDD:338972	16/55 (29%)
		LRR 8	246..267		6/20 (30%)
		leucine-rich repeat	247..270	CDD:275380	5/22 (23%)
		LRR 9	270..291		7/20 (35%)
		leucine-rich repeat	271..292	CDD:275380	7/20 (35%)
		LRR 10	294..315		6/20 (30%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		LRR 11	318..339		5/20 (25%)
		leucine-rich repeat	321..342	CDD:275380	5/20 (25%)
		PCC	331..>405	CDD:188093	21/83 (25%)
		I-set	406..496	CDD:369462
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940