DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and SLITRK3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001305739.1	Gene:	SLITRK3 / 22865	HGNCID:	23501	Length:	977	Species:	Homo sapiens

Alignment Length:	619	Identity:	138/619 - (22%)
Similarity:	222/619 - (35%)	Gaps:	194/619 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 VEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFT-------CWN---------TNLKSVPVTQVI 179
            |::.::|:         ||         |:|.||       .|:         .:::.:.....:
Human    52 VKESLFHI---------HC---------DSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFL 98

  Fly   180 PM-NMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLED 243
            .: |.|:|:|..|.|..:....|.||.:||.|.:..|.||....|.|..|:||..|:...|.::.
Human    99 HLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163

  Fly   244 IDHRTFWKLRNLNILDLSKNEIGMLPESIF---------YHAQRLTVI---NMCDN--------Q 288
            |:...|..|..|.:|.|:.|.|.|||.::|         ....||.|:   .|.|:        |
Human   164 IESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQ 228

  Fly   289 IQNFPPN-----------------------------------------------LLRDQLMLEEL 306
            ::..|.|                                               ||.|..:...|
Human   229 LEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASL 293

  Fly   307 DMSRNKISE-----------LSS-----GSIRYLTKLK--------------------------- 328
            .:..:..|:           |||     .|:.|.:..|
Human   294 GIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP 358

  Fly   329 ---------------------------------TLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNR 360
                                             ..:.|:|.|:::    .....:.:.|.|.:|.
Human   359 PIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISEL----LPRPLNAKKLYLSSNL 419

  Fly   361 ISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTR 425
            |..:..:.|.|.::|..|.|..||||::...||:.|.||..|||..|.:..:...:|..:.:|..
Human   420 IQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHY 484

  Fly   426 LTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLP-HGAL 489
            |....|.:..::...|..:.|||:|.||||:|:.....||...| |.:|.:..|..::|| .|.|
Human   485 LYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTS-LARLNLRKNYFLYLPVAGVL 548

  Fly   490 HGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCD 554
            ..|..:|.:.|::|||.|.|..:...:|| |.:..:......:||.|.:|...:|..:..:.||
Human   549 EHLNAIVQIDLNENPWDCTCDLVPFKQWI-ETISSVSVVGDVLCRSPENLTHRDVRTIELEVLC- 611

  Fly   555 GQWASMLSL-----SPRLPVRKHQISTPMNYTDY 583
               ..||.:     ||..|...|.|..|.:.:.|
Human   612 ---PEMLHVAPAGESPAQPGDSHLIGAPTSASPY 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/58 (38%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	61/327 (19%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	21/126 (17%)
		leucine-rich repeat	255..278	CDD:275380	9/31 (29%)
		leucine-rich repeat	279..302	CDD:275380	10/80 (13%)
		LRR_8	303..361	CDD:290566	14/133 (11%)
		leucine-rich repeat	303..326	CDD:275380	7/38 (18%)
		leucine-rich repeat	327..350	CDD:275380	4/82 (5%)
		LRR_8	349..407	CDD:290566	21/57 (37%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	10/22 (45%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	8/23 (35%)
		LRRCT	503..554	CDD:214507	14/50 (28%)
SLITRK3	NP_001305739.1	leucine-rich repeat	81..102	CDD:275380	0/20 (0%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR_8	105..161	CDD:316378	20/55 (36%)
		leucine-rich repeat	127..150	CDD:275380	9/22 (41%)
		LRR_8	150..208	CDD:316378	16/57 (28%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..197	CDD:275380	9/21 (43%)
		leucine-rich repeat	198..402	CDD:275380	22/203 (11%)
		leucine-rich repeat	224..271	CDD:275380	3/46 (7%)
		LRRCT	232..>270	CDD:214507	2/37 (5%)
		leucine-rich repeat	272..410	CDD:275380	14/141 (10%)
		leucine-rich repeat	403..433	CDD:275380	6/33 (18%)
		LRR_8	432..492	CDD:316378	20/59 (34%)
		leucine-rich repeat	434..457	CDD:275380	10/22 (45%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		leucine-rich repeat	482..501	CDD:275380	3/18 (17%)
		leucine-rich repeat	506..528	CDD:275380	10/21 (48%)
		leucine-rich repeat	529..553	CDD:275380	8/23 (35%)
		LRRCT	562..>597	CDD:214507	11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910