DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Chadl

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_006520805.1	Gene:	Chadl / 214685	MGIID:	3036284	Length:	759	Species:	Mus musculus

Alignment Length:	463	Identity:	124/463 - (26%)
Similarity:	178/463 - (38%)	Gaps:	98/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DVNGGEIN-AMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSF 163
            ::.|||:: ..|.:..|.|:..:..::|       |.||:|.      ..|.. .|.|:...:..
Mouse     6 ELQGGEMDRPQSSIWVFMLLLFMVLLQS-------PAWHVAA------QRCPQ-TCVCDNSRRHV 56

  Fly   164 TCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDL 228
            ||.:.||..||.|  ||                        .:.:.||:..|:|..||...||||
Mouse    57 TCRHQNLTEVPNT--IP------------------------ELTQRLDLQGNILKVLPAAAFQDL 95

  Fly   229 DSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFP 293
            ..|..|.::|.|:|                        |:.|..|....||.::|:..|::...|
Mouse    96 PHLTHLDLRNCQVE------------------------MVAEGAFRGLGRLLLLNLASNRLSTLP 136

  Fly   294 PNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHN 358
            ...|.....|..|::..|.:.||..|:                        |..|.||.||:|.:
Mouse   137 QEALDGLGSLRRLELEGNMLEELRPGT------------------------FGALGSLTTLNLAH 177

  Fly   359 NRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSAL 423
            |.:..|....|..|.....|.|:.|.:|.:...|...|..|..|.|..|.:.::|........:|
Mouse   178 NALVYLPAMAFQGLLRTRWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGAALSQARSL 242

  Fly   424 TRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGA 488
            .||.|..|.||....:|...|..|:.|.|::..|:....|||....:|..|.:..|:|..||...
Mouse   243 ARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQ 307

  Fly   489 LHGLKNLVAVKLDKNPWHCDCRALYLARW-IREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDL 552
            :.|  .|..::|..||..|.|.|..|..| :|..|..  ||   .||||..|.|..:..||..||
Mouse   308 VPG--QLRRLRLQGNPLWCACHARPLLEWLVRARVRS--DG---ACRGPRRLRGEALDTLRPSDL 365

  Fly   553 -CDGQWAS 559
             |.|..|:
Mouse   366 RCPGDAAA 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/58 (22%)
		leucine-rich repeat	187..206	CDD:275380	0/18 (0%)
		LRR_RI	<201..386	CDD:238064	44/184 (24%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	12/59 (20%)
		leucine-rich repeat	255..278	CDD:275380	3/22 (14%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	21/52 (40%)
Chadl	XP_006520805.1	PRK15370	<32..>322	CDD:185268	95/379 (25%)
		leucine-rich repeat	54..72	CDD:275380	9/43 (21%)
		leucine-rich repeat	74..97	CDD:275380	10/22 (45%)
		leucine-rich repeat	98..121	CDD:275380	8/46 (17%)
		leucine-rich repeat	122..145	CDD:275380	5/22 (23%)
		leucine-rich repeat	146..169	CDD:275380	8/46 (17%)
		LRR_8	169..228	CDD:338972	19/58 (33%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	9/22 (41%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	312..351	CDD:275380	17/43 (40%)
		LRRNT	405..439	CDD:214470
		leucine-rich repeat	437..460	CDD:275380
		LRR_8	460..519	CDD:338972
		leucine-rich repeat	461..484	CDD:275380
		leucine-rich repeat	485..508	CDD:275380
		LRR	<507..>687	CDD:227223
		leucine-rich repeat	509..532	CDD:275380
		leucine-rich repeat	533..556	CDD:275380
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..629	CDD:275380
		leucine-rich repeat	630..653	CDD:275380
		leucine-rich repeat	655..677	CDD:275380
		LRRCT	685..733	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840