DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and sym-1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_510426.1	Gene:	sym-1 / 181555	WormBaseID:	WBGene00006366	Length:	680	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	127/554 - (22%)
Similarity:	214/554 - (38%)	Gaps:	128/554 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DGDVNGGEINAMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKS 162
            |..|.|..|....|              ..||.||:    |:|.:.:|.....
Worm    32 DSTVEGPVIKCSGH--------------DGLRMVEK----LSTTTTMEVRELA------------ 66

  Fly   163 FTCWNTNLKSVPVTQVIP-----MNMVNIDLSRNILSTLHKDTFRGL-TVLKELDISHNVLDFLP 221
                   |::..:.:|.|     :.:..:.||.|.:..:|...|.|| .|::||.:|.|.|..:|
Worm    67 -------LENADIIEVGPKAFKTLRIKKLILSNNRIEKIHDHAFTGLENVMQELSLSENNLKEVP 124

  Fly   222 FDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCD 286
            ......|..|.:|.::.|::|:|..:.|..:.:|..::|..|:|..:....|.:.
Worm   125 TSALAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANV---------- 179

  Fly   287 NQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSL 351
                         ::.|:.|.:..|.::|..|.::|.:..|..|...:|:|..|..:.|..|.||
Worm   180 -------------KMSLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSL 231

  Fly   352 RTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADL 416
            ..|||:.|.||.:.|....|..||..|.|..|.:..:|.....:...|..|.|..|:.:.|..::
Worm   232 SMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEM 296

  Fly   417 FLNVSALTRLTLFSNNLTTLEADDFQGL--------NN---------------LKILLLNNNILK 458
            |..:.::..|.|.||.::.:....|.|.        ||               |:::.|:||.::
Worm   297 FEGLESIQHLNLDSNRISAVAPGAFAGTPLLLLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIR 361

  Fly   459 NFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYL-----ARWI 518
            .....:|:.|..|..|.:.:||:|.|.:.:|.|.:|| ||:|.:||..|.....::     |.|:
Worm   362 EVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENL-AVRLQENPVVCVKNGFHVLNSGEAIWL 425

  Fly   519 REFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQW-ASMLSLSPRL---PVRKHQISTPMN 579
            ..                           ..:.:|.|:| |....|.|:.   |:|....|..:.
Worm   426 TN---------------------------EANTICKGEWQAQTADLCPKAQPRPIRPVCCSNEIT 463

  Fly   580 YTDYFNLYLKHIYNGTTDEELKEADITSVSIKKV 613
            .|.........:...||.||.||.  |:.:.:||
Worm   464 TTTTTTTTTTTLAPTTTTEEEKEE--TTETTEKV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/59 (31%)
		leucine-rich repeat	187..206	CDD:275380	7/19 (37%)
		LRR_RI	<201..386	CDD:238064	50/185 (27%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	8/59 (14%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	19/57 (33%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	15/39 (38%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	5/55 (9%)
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380	3/37 (8%)
		LRR_5	74..208	CDD:290045	34/156 (22%)
		LRR_RI	81..384	CDD:238064	78/325 (24%)
		leucine-rich repeat	86..108	CDD:275380	7/21 (33%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	158..182	CDD:275380	5/46 (11%)
		LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	302..384	CDD:290566	17/81 (21%)
		leucine-rich repeat	303..323	CDD:275380	5/19 (26%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
		leucine-rich repeat	374..394	CDD:275380	7/19 (37%)
		leucine-rich repeat	399..410	CDD:275378	5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910