DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and egg-6

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	479	Identity:	122/479 - (25%)
Similarity:	206/479 - (43%)	Gaps:	50/479 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VNGGEINAMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTC 165
            :||.::...|  ..|:.::.:..:.|.|:|.          |...|.|..:.:       :..|.
Worm    66 LNGTDVKIES--LPFNGLRTIAILNSTLQSF----------SPTAWRHVEATI-------EHITI 111

  Fly   166 WNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHN-VLDFLPFDLFQDLD 229
            ....||:|||...: ..:::::|:.|.:|::....|.||:.|.:|.:.:| :.||.|..|.....
Worm   112 NGNELKTVPVFGNL-STLMSMNLNSNQISSIPDKAFNGLSALTQLRLENNAICDFPPKSLDAVKA 175

  Fly   230 SLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPP 294
            ||::|.:..|.|:.|..:......||..|||..|.|..:......:...|..:.:.:|.::...|
Worm   176 SLVLLDVSGNCLDAIPAQILRNAANLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHP 240

  Fly   295 NLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNN 359
            ....:...|:.|.:..|.||.|....::....|:.||...|.:..:..  ...|.:|:.:.:..|
Worm   241 MAFMNVPQLQYLYLQDNIISTLDGNRLQGFKNLEVLDVSNNALYALPS--LKDLPNLKQVRVDGN 303

  Fly   360 RISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALT 424
            .|:.:....|:|..||..:.:..|.|..|..|:|..|:.|..|.:|.||::.|...:|..:..|.
Worm   304 LITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMKNLQ 368

  Fly   425 RLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGAL 489
            :|::.:|.||.|:|..|..|.:|..|.|.:|.:.:.:...|:.||:|..|.:.:||        :
Worm   369 QLSIRNNTLTALDASSFAQLAHLTTLDLGHNKIHDIEEGTFDKLSKLFWLDLSNNK--------I 425

  Fly   490 HGLKNLVAVK------LDKNPWHCD-----CRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHE 543
            .|.|..|..|      ||.|...||     .....:|..:|.|   |...|:.||.||....|
Worm   426 SGFKTSVFKKKISNILLDGNQLICDESFNEFLTYLIANKVRTF---LPFQQEIMCHGPEKYAG-- 485

  Fly   544 VGLLRYDDLCDGQWASMLSLSPRL 567
               :|..||...:....||...||
Worm   486 ---VRLKDLMMKKANETLSEGSRL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/59 (29%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	45/185 (24%)
		leucine-rich repeat	207..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	13/59 (22%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	13/57 (23%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	16/57 (28%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	16/55 (29%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	15/55 (27%)
		leucine-rich repeat	107..127	CDD:275380	6/20 (30%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		LRR_RI	<144..281	CDD:238064	35/136 (26%)
		leucine-rich repeat	152..200	CDD:275380	13/47 (28%)
		LRR_8	176..233	CDD:290566	14/56 (25%)
		leucine-rich repeat	201..224	CDD:275380	6/22 (27%)
		LRR_8	225..283	CDD:290566	13/57 (23%)
		leucine-rich repeat	225..248	CDD:275380	3/22 (14%)
		LRR_RI	<240..458	CDD:238064	61/227 (27%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		LRR_8	271..329	CDD:290566	13/59 (22%)
		leucine-rich repeat	273..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..318	CDD:275380	5/22 (23%)
		LRR_8	317..375	CDD:290566	17/57 (30%)
		leucine-rich repeat	319..342	CDD:275380	7/22 (32%)
		leucine-rich repeat	343..366	CDD:275380	7/22 (32%)
		LRR_8	365..425	CDD:290566	20/67 (30%)
		leucine-rich repeat	367..390	CDD:275380	9/22 (41%)
		leucine-rich repeat	391..414	CDD:275380	6/22 (27%)
		leucine-rich repeat	415..434	CDD:275380	7/26 (27%)
		leucine-rich repeat	437..449	CDD:275378	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910