DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and lron-9

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001076615.1	Gene:	lron-9 / 172529	WormBaseID:	WBGene00011971	Length:	653	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	128/485 - (26%)
Similarity:	202/485 - (41%)	Gaps:	72/485 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 KSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLF 225
            ::.|....||:::|.:.....|:..:..|.|.|.:|..|.|:....|..||:|.|.:..:....|
Worm   138 RNLTIHACNLQTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAF 202

  Fly   226 QDLDSLLVLRI-QNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQI 289
            :.|.||..|.| ::|.:.:.......:|:.|..||||:      .:.||.
Worm   203 EPLTSLETLVIGEHNFINETVVEEIGRLKALKTLDLSR------ADGIFQ--------------- 246

  Fly   290 QNFPPNLLRDQL-MLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRT 353
               ||..|..:: .:|.|.:|...|..|..|....|.|||.||...|.|..|....|.||.||..
Worm   247 ---PPETLFKEIPQIEVLKLSGCSIPTLEPGQFATLKKLKELDLRVNLIENITAYAFDGLESLTR 308

  Fly   354 LSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVEL-NNLNELFLGQNSMSSIPADLF 417
            |||..|.||.|...:|..|::|..|||..|.|..|..:.|..| :.|..:.|..|.:|.:|:
Worm   309 LSLAGNFISKLEPDVFFGLSSLEELDLGWNEIKTIPTDVFKPLTDKLKTISLRNNPISELPS--- 370

  Fly   418 LNVSALTRLTLFSNNLTTLEAD---DFQGLNNLKILLLN-NNILKNFDARAFE-PLSQLEKLRID 477
            ..:..|.:|:|.....|::.||   |:..|..|.:...| :||::|    .|| ....|:||.:.
Worm   371 TGLGMLEKLSLAECGFTSISADQLKDYPKLEELDLSKCNISNIVEN----TFENQKDSLKKLNLQ 431

  Fly   478 SNKLMFLPHGALHGLKNLVAVK---LDKNPWHCDCRALYLARWIREFVLKLWDG---------QQ 530
            .|||..||    :.:|||.|::   :..||:.||...:.....:.:.|.|..:.         .:
Worm   432 KNKLKSLP----NLIKNLPAIESLDVSSNPYRCDGELVNFVFGVEDRVKKAEENGNSFFVANTNE 492

  Fly   531 PMCRGPGDLGGHEVGLLR------YDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTDYFNLYLK 589
            .:|..|..|.|.::..:.      ||:..|...|...:.:..:.....::..|       :|.:.
Worm   493 TVCDRPYTLRGEQILQVEVEKFQPYDEKSDTTTAPSTTTTSTVEETTTELKIP-------DLLVG 550

  Fly   590 HIYNGTTDEELKEADITSVS----IKKVHN 615
            ...|.|..:|....|:..:|    .|.|:|
Worm   551 SRTNDTLFKEEPRRDVYDLSKTDDAKGVYN 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/59 (32%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	58/186 (31%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	5/23 (22%)
		LRR_8	253..313	CDD:290566	13/60 (22%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	3/23 (13%)
		LRR_8	303..361	CDD:290566	24/57 (42%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	10/22 (45%)
		LRR_8	349..407	CDD:290566	22/58 (38%)
		LRR_4	350..390	CDD:289563	18/39 (46%)
		leucine-rich repeat	351..374	CDD:275380	10/22 (45%)
		leucine-rich repeat	375..398	CDD:275380	9/23 (39%)
		LRR_8	398..>443	CDD:290566	12/47 (26%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	12/65 (18%)
lron-9	NP_001076615.1	leucine-rich repeat	137..159	CDD:275380	4/20 (20%)
		LRR_8	159..217	CDD:290566	18/57 (32%)
		leucine-rich repeat	160..183	CDD:275380	6/22 (27%)
		leucine-rich repeat	184..207	CDD:275380	7/22 (32%)
		leucine-rich repeat	208..232	CDD:275380	5/23 (22%)
		LRR_8	233..292	CDD:290566	23/82 (28%)
		leucine-rich repeat	233..257	CDD:275380	10/47 (21%)
		LRR_RI	234..456	CDD:238064	79/256 (31%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		LRR_8	280..340	CDD:290566	27/59 (46%)
		leucine-rich repeat	282..305	CDD:275380	10/22 (45%)
		leucine-rich repeat	306..329	CDD:275380	10/22 (45%)
		LRR_8	328..410	CDD:290566	23/84 (27%)
		leucine-rich repeat	330..375	CDD:275380	14/47 (30%)
		leucine-rich repeat	376..399	CDD:275380	7/22 (32%)
		LRR_8	398..457	CDD:290566	20/66 (30%)
		leucine-rich repeat	400..420	CDD:275380	7/23 (30%)
		leucine-rich repeat	425..447	CDD:275380	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910