DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Y54E10A.6

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001380012.1	Gene:	Y54E10A.6 / 171890	WormBaseID:	WBGene00021828	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	182/474 - (38%)	Gaps:	128/474 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 INAMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNL 170
            |::::..||.. .|||.:..|:|..:.      .||..:  ::.:|.:..|:
Worm    26 IDSVTEAANLS-QKRVFESMSQLNLLS------LTGCSL--HNLSSSIRSCS------------- 68

  Fly   171 KSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDL--FQDLDSLLV 233
                       |::::.|.:|.|..| .|.|..|..||.:|:|||.||.||..:  .::|:||:
Worm    69 -----------NLMHLVLPKNDLKQL-PDVFDCLPKLKFMDLSHNHLDALPASISKCENLESLI- 120

  Fly   234 LRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYH--AQRLTVINMCDNQIQNFPPNL 296
              :.||:|.:........|.||:|.|.:.|.|..:|.|:..|  :.:|..|.:..|.|:..|.:
Worm   121 --LNNNRLNESSFPDISNLSNLHIFDAAHNTISKIPASLTSHNLSAKLHTIILSHNSIEVIPDS- 182

  Fly   297 LRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLD-----FGWNQIAKIDDDFFAGLRSLRTL-- 354
            |.:...|:||.:..||:.::.| .|.:|.|||.||     |..::..|:.:|....|.::..|
Worm   183 LSNLKQLKELKIDENKLKDVPS-VIAHLPKLKVLDISKNCFSESRFQKLANDKRGKLNAVIALAQ 246

  Fly   355 -------SLHNNRISSLSG-----------TIFNNLANLVTLDLTTNR---------------IS 386
                   :....:.:..||           |:...:.|     ||..|               |:
Worm   247 KIGKPIGNSEEQKKAPESGSPDFPVPDAPLTVRTGIEN-----LTVRRHPSVSEIRPYLVCCVIN 306

  Fly   387 HIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQ--------G 443
            ::|.|.            |.:....|.....::.|||......| .:.|...|.||        .
Worm   307 NVDLNG------------GDSFKKFIALQTKMHASALCENRTLS-AIGTHRLDSFQLPLCYMALP 358

  Fly   444 LNNLKILLLNNNILKNFDARAFEPLSQL----EKLRIDSNKLMFLP-HGALHGLK--NLVAVKLD 501
            .:.|.|..||    |.....|.|.|..|    |..|..|.:....| |..||.:|  |::|..:|
Worm   359 KDELYIRALN----KKSSVSASELLDSLLRDAELARKRSKRSTVDPLHKYLHIVKDENILACLVD 419

  Fly   502 KNP--------WHCDCRAL 512
            ...        .:.||..|
Worm   420 SQQIVISLPPITNSDCTKL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	23/60 (38%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	59/228 (26%)
		leucine-rich repeat	207..230	CDD:275380	11/24 (46%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	19/61 (31%)
		leucine-rich repeat	255..278	CDD:275380	8/24 (33%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	18/71 (25%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/27 (30%)
		LRR_8	349..407	CDD:290566	12/92 (13%)
		LRR_4	350..390	CDD:289563	9/74 (12%)
		leucine-rich repeat	351..374	CDD:275380	4/42 (10%)
		leucine-rich repeat	375..398	CDD:275380	6/37 (16%)
		LRR_8	398..>443	CDD:290566	10/52 (19%)
		leucine-rich repeat	399..422	CDD:275380	2/22 (9%)
		leucine-rich repeat	423..443	CDD:275380	6/27 (22%)
		leucine-rich repeat	471..494	CDD:275380	9/29 (31%)
		LRRCT	503..554	CDD:214507	3/18 (17%)
Y54E10A.6	NP_001380012.1	LRR	<45..>219	CDD:227223	59/211 (28%)
		leucine-rich repeat	47..69	CDD:275380	5/53 (9%)
		leucine-rich repeat	70..92	CDD:275380	7/22 (32%)
		leucine-rich repeat	93..115	CDD:275380	10/21 (48%)
		leucine-rich repeat	116..139	CDD:275380	7/25 (28%)
		leucine-rich repeat	140..164	CDD:275380	8/23 (35%)
		leucine-rich repeat	166..188	CDD:275380	6/22 (27%)
		leucine-rich repeat	189..211	CDD:275380	8/22 (36%)
		PLN02265	266..>495	CDD:215149	41/195 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910