DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lron-11

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_491035.1	Gene:	lron-11 / 171837	WormBaseID:	WBGene00022129	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	120/409 - (29%)
Similarity:	196/409 - (47%)	Gaps:	35/409 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 CTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDIS 213
            |.|| |:| |...:..|..::|:|:|:. :.|...| :|||.|.:|.|..|.......|::|.:.
Worm    18 CQSG-CKC-PTKTTAVCKGSSLRSIPIL-LDPRTTV-LDLSNNRISRLSADELSLYPNLEQLILH 78

  Fly   214 HNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQR 278
            :|.:..|..|:|..|.||.||.:.:|.|..:.:..|.||:||..|.:|.|::.:.|| .|....:
Worm    79 NNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNEVFSKLKNLKTLIISSNDVQLGPE-CFAGLSQ 142

  Fly   279 LTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDD 343
            |..:::.||::...||::|:....|..||:|.||:..:.:..:..|..|:||....|.::.::..
Worm   143 LQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLLSSLETG 207

  Fly   344 FFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQN- 407
            .|...:.|:.|.:..|.|..:.......|..|.||:||.|::..:.||.: .|..|..|.|..|
Worm   208 MFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVRLPGNTW-SLPALKTLDLSSNL 271

  Fly   408 -------SMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAF 465
                   |...:||..:||:|       .|.||.|::...|..|::|..|.::::.|.:....||
Worm   272 FVSLETASFDGLPALQYLNIS-------HSRNLKTIQMATFVQLSSLHWLSISSSALTHIHPSAF 329

  Fly   466 EPLSQLEKLRIDSNKLMFLPHGALH--GLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDG 528
            .|:..|..|.:.:|:|.::..|.|.  .::||   .|..|.|||.|.       :|  |..|...
Worm   330 NPIPPLSHLDLSNNELRYVAPGMLQWPNIRNL---HLANNDWHCSCD-------LR--VSNLNPR 382

  Fly   529 QQPMCRGPGDLGGHEVGLL 547
            ....|.||.:|.|..:..|
Worm   383 DDAKCSGPENLAGAPINEL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	53/184 (29%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	19/59 (32%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	11/39 (28%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	15/52 (29%)
		leucine-rich repeat	399..422	CDD:275380	9/30 (30%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	6/24 (25%)
		LRRCT	503..554	CDD:214507	14/45 (31%)
lron-11	NP_491035.1	leucine-rich repeat	48..71	CDD:275380	8/23 (35%)
		LRR_RI	<50..177	CDD:238064	43/128 (34%)
		LRR_8	70..130	CDD:290566	21/59 (36%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		leucine-rich repeat	96..119	CDD:275380	8/22 (36%)
		LRR_8	118..177	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..142	CDD:275380	7/22 (32%)
		LRR_RI	<141..270	CDD:238064	35/129 (27%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		LRR_8	190..249	CDD:290566	16/58 (28%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		LRR_8	238..295	CDD:290566	19/64 (30%)
		leucine-rich repeat	239..261	CDD:275380	9/22 (41%)
		leucine-rich repeat	262..283	CDD:275380	5/20 (25%)
		LRR_8	284..345	CDD:290566	20/67 (30%)
		leucine-rich repeat	286..310	CDD:275380	9/30 (30%)
		leucine-rich repeat	311..334	CDD:275380	6/22 (27%)
		leucine-rich repeat	335..357	CDD:275380	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H137689
Inparanoid	1	1.050	158	1.000	Inparanoid score	I2900
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.000