Protein Alignment CG7509 and tol-1

DIOPT Version :9

• Sequence 1: NP_647931.1
• Gene: CG7509 / 38579
• FlyBaseID: FBgn0035575
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_001020983.1
• Gene: tol-1 / 171635
• WormBaseID: WBGene00006593
• Length: 1221
• Species: Caenorhabditis elegans
• Alignment Length: 608
• Identity: 146/608 - (24%)
• Similarity: 249/608 - (40%)
• Gaps: 138/608 - (22%)

  Fly    31 PIQSLDEFR----------QRYLLPLISSDTRNCSLNACESL----GIVSQLLMLINSMPNGTQS 81
            |:..|::|.          ||.|..|......|.|.|...||    ..|:|.|::::...|
 Worm   144 PLARLEKFSLTRSRNIELPQRLLCSLPHLQVLNISSNELPSLRREESCVAQQLLIVDLSRN---- 204

  Fly    82 AANDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKR----VRQIESRLRSVEQPVWHLATG- 141
                                         .|.|.:...|    :|||.....|:.:....|||.
 Worm   205 -----------------------------RLTNIEQFLRGIPAIRQISVAYNSIAELDLSLATPF 240

  Fly   142 -SQI--EWNHCTSGVCRCNPDTKSF--TCWNTN-----LKSVPVTQVIPMNMVNIDLSRNILSTL 196
             .|:  |.|...        |..|.  |..:.|     ||.||.......::|.:::|||.:...
 Worm   241 LQQLDAEANRIV--------DLTSLPGTVVHVNLAGNALKRVPDAVAELASLVALNVSRNEIEAG 297

  Fly   197 HKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLV-LRIQNNQLEDIDHRTFWKLRNLNILDL 260
            :...|.. ..|:.||.|:|.||.||.:..|..:..:. |.:::|.:|.:.........||..|||
 Worm   298 NSSVFSS-PELEMLDASYNKLDSLPVEWLQKCEKRIAHLHLEHNSIEQLTGGVLANATNLQTLDL 361

  Fly   261 SKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLT 325
            |.|::.:..:.:.....::..:.:.:|.::...|:.| ..|.||.||:|.||::|:.: :|..:.
 Worm   362 SSNQLRVFRDEVLPENSKIGNLRLSNNSLELLEPSSL-SGLKLESLDLSHNKLTEVPA-AIGKVE 424

  Fly   326 KLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDG 390
            :||.:|...|:|||:.......::.|.|:.|.||::.|:...||::.:.|.:||::.|.||.:..
 Worm   425 QLKKVDLSHNRIAKVYQYVLNKIKQLHTVDLSNNQLQSIGPYIFSDSSELHSLDVSNNEISLLFK 489

  Fly   391 NAFVELNNLNELFLGQNSM----------------------------SSIPADL-FLN-----VS 421
            :||.....|.::.:..|.:                            |::|.:| .||     ::
 Worm   490 DAFARCPKLRKISMKMNKIKSLDEGLTEASGLRRLDVSHNEILVLKWSALPENLEILNADNNDIN 554

  Fly   422 ALT------------RLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKL 474
            .||            .::|.:|.:|.:.||...  |:|:.|.::||.|......|....|||.:|
 Worm   555 LLTAASMSPSTANLKSVSLSNNGITIMNADQIP--NSLESLDVSNNRLAKLGKTALAAKSQLRRL 617

  Fly   475 RIDSNKLMFLPH------GALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMC 533
            .:..|.|..:..      .|:|.||    |::.:||..|||:..::....:..|| :.|.:...|
 Worm   618 NLKGNLLTVVATESMKVVEAVHPLK----VEISENPLICDCQMGWMIGGAKPKVL-IQDSETASC 677

  Fly   534 RGPGDLGGHEV---GLLRYDDLC 553
            ....|  ||::   .|.:.|.||
 Worm   678 SHAVD--GHQIQIQSLSKKDLLC 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/59 (29%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	53/185 (29%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	3/23 (13%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	14/90 (16%)
		leucine-rich repeat	399..422	CDD:275380	7/56 (13%)
		leucine-rich repeat	423..443	CDD:275380	7/31 (23%)
		leucine-rich repeat	471..494	CDD:275380	7/28 (25%)
		LRRCT	503..554	CDD:214507	16/54 (30%)
tol-1	NP_001020983.1	leucine-rich repeat	71..95	CDD:275380
		leucine-rich repeat	96..119	CDD:275380
		leucine-rich repeat	120..171	CDD:275380	7/26 (27%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..283	CDD:275380	23/127 (18%)
		leucine-rich repeat	219..240	CDD:275378	7/20 (35%)
		leucine-rich repeat	241..258	CDD:275378	5/24 (21%)
		LRR	265..600	CDD:227223	85/339 (25%)
		leucine-rich repeat	287..306	CDD:275380	4/19 (21%)
		leucine-rich repeat	307..331	CDD:275380	10/23 (43%)
		leucine-rich repeat	332..355	CDD:275380	3/22 (14%)
		leucine-rich repeat	356..379	CDD:275380	6/22 (27%)
		leucine-rich repeat	380..395	CDD:275380	1/14 (7%)
		leucine-rich repeat	403..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..520	CDD:275380	2/21 (10%)
		leucine-rich repeat	543..567	CDD:275380	5/23 (22%)
		leucine-rich repeat	568..589	CDD:275380	5/22 (23%)
		leucine-rich repeat	590..613	CDD:275380	6/22 (27%)
		leucine-rich repeat	614..633	CDD:275380	4/18 (22%)
		leucine-rich repeat	763..785	CDD:275378
		LRR_8	785..844	CDD:338972
		leucine-rich repeat	786..809	CDD:275378
		LRR_9	<806..>890	CDD:373143
		leucine-rich repeat	810..833	CDD:275378
		leucine-rich repeat	834..857	CDD:275378
		leucine-rich repeat	858..879	CDD:275378
		leucine-rich repeat	880..892	CDD:275378
		TIR_2	1056..1194	CDD:390066

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910