DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrrn3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001258637.1	Gene:	Lrrn3 / 16981	MGIID:	106036	Length:	707	Species:	Mus musculus

Alignment Length:	411	Identity:	104/411 - (25%)
Similarity:	164/411 - (39%)	Gaps:	70/411 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 RCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDF 219
            |...||:.......|:..:..:...|:|:..:|||:|.||::.....:.::.|..:.:..|.|..
Mouse    66 RLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTE 130

  Fly   220 LPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINM 284
            ||......|.:|..|.:.:|.|..|....|..|.||..|.|:.|.:.|:....|.....|.::.:
Mouse   131 LPEKCLYGLSNLQELYVNHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSQWFDALPNLEILML 195

  Fly   285 CDNQI-----QNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDF 344
            .||.|     .||.|                             |.||::|......:.:|.||.
Mouse   196 GDNPIIRIKDMNFQP-----------------------------LVKLRSLVIAGINLTEIPDDA 231

  Fly   345 FAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSM 409
            .|||.:|.::|.::||:|.:.........||..|||..|.|:.|....|..:.:|.||.:
Mouse   232 LAGLENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGI----- 291

  Fly   410 SSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNL----KILLLNNNILKNFDARAFEPLSQ 470
                                 ||:..|.:.|...::||    ||...||..|......||..|.:
Mouse   292 ---------------------NNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPK 335

  Fly   471 LEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWI--REFVLKLWDGQQPMC 533
            ||.|.:::|.|..|.||.:..|.||..:.:..||..|||    :.|||  .:..::..:.....|
Mouse   336 LESLMLNTNALSALYHGTIESLPNLKEISIHSNPIRCDC----VIRWINMNKTNIRFMEPDSLFC 396

  Fly   534 RGPGDLGGHEVGLLRYDDLCD 554
            ..|.:..|..|..:.:.|:.:
Mouse   397 VDPPEFQGQNVRQVHFRDMME 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	48/189 (25%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	14/64 (22%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	7/27 (26%)
		LRR_8	303..361	CDD:290566	13/57 (23%)
		leucine-rich repeat	303..326	CDD:275380	1/22 (5%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	7/44 (16%)
		leucine-rich repeat	399..422	CDD:275380	3/22 (14%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	9/22 (41%)
		LRRCT	503..554	CDD:214507	13/52 (25%)
Lrrn3	NP_001258637.1	LRRNT	28..72	CDD:214470	2/5 (40%)
		LRR 1	70..91		3/20 (15%)
		leucine-rich repeat	72..93	CDD:275380	2/20 (10%)
		LRR_8	93..152	CDD:290566	16/58 (28%)
		LRR 2	93..114		7/20 (35%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		LRR 3	117..138		5/20 (25%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR	139..160	CDD:197688	6/20 (30%)
		LRR 4	141..162		6/20 (30%)
		leucine-rich repeat	142..165	CDD:275380	7/22 (32%)
		LRR 5	165..186		7/20 (35%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		LRR_8	173..221	CDD:290566	14/76 (18%)
		LRR 6	189..210		6/20 (30%)
		leucine-rich repeat	190..213	CDD:275380	8/51 (16%)
		LRR_8	213..272	CDD:290566	20/58 (34%)
		LRR 7	213..234		6/20 (30%)
		leucine-rich repeat	214..237	CDD:275380	8/22 (36%)
		LRR 8	237..258		5/20 (25%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		LRR 9	261..282		9/20 (45%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		LRR 10	285..304		7/44 (16%)
		leucine-rich repeat	286..310	CDD:275380	9/49 (18%)
		LRR 11	310..332		7/21 (33%)
		LRR_8	311..370	CDD:290566	20/58 (34%)
		leucine-rich repeat	311..333	CDD:275380	7/21 (33%)
		LRR 12	335..358		8/22 (36%)
		leucine-rich repeat	336..359	CDD:275380	9/22 (41%)
		LRRCT	368..419	CDD:214507	13/54 (24%)
		I-set	429..513	CDD:254352
		Ig	440..513	CDD:299845
		fn3	526..593	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910