DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrrn2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_034862.1	Gene:	Lrrn2 / 16980	MGIID:	106037	Length:	730	Species:	Mus musculus

Alignment Length:	399	Identity:	103/399 - (25%)
Similarity:	159/399 - (39%)	Gaps:	94/399 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 QVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQL 241
            |.:| .::::.|..|.|:.|...:|.|||.|:||.::||.|..:....|..|.:||.|.:.:|.|
Mouse   114 QALP-QLLSLHLEENRLNRLEDHSFAGLTSLQELYLNHNQLCRISPRAFAGLGNLLRLHLNSNLL 177

  Fly   242 EDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEEL 306
            ..||.|.|..|.||.||.:..|::..:                                     |
Mouse   178 RTIDSRWFEMLPNLEILMIGGNKVDAI-------------------------------------L 205

  Fly   307 DMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNN 371
            ||           :.|.|..|::|......:.:|.|....||:||.:||.::|:::.:.......
Mouse   206 DM-----------NFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQ 259

  Fly   372 LANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMS---SIPADLFLNVSALTRLTLFSNNL 433
            :..|..|||..|.:..:....|..:.:|.|  ||.|:|.   ||.....:|:..||:|.
Mouse   260 VPGLKFLDLNKNPLQRVGPGDFANMLHLKE--LGLNNMEELVSIDKFALVNLPELTKLD------ 316

  Fly   434 TTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAV 498
                             :.||..|.....|||..|.|:|.|.:::|.|..|....:..|.||..|
Mouse   317 -----------------ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364

  Fly   499 KLDKNPWHCDCRALYLARWIR------EFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQW 557
            .|..||..|||    :.||..      .|:    :.|..:|..|.||....|..:.:.::.|
Mouse   365 GLHGNPIRCDC----VIRWANATGTHVRFI----EPQSTLCAEPPDLQRRPVREVPFREMTD--- 418

  Fly   558 ASMLSLSPR 566
            ..:..:|||
Mouse   419 HCLPLISPR 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	48/184 (26%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	10/22 (45%)
		LRR_8	253..313	CDD:290566	8/59 (14%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	15/57 (26%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	12/47 (26%)
		leucine-rich repeat	399..422	CDD:275380	9/25 (36%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	14/56 (25%)
Lrrn2	NP_034862.1	leucine-rich repeat	51..69	CDD:275380
		LRR_RI	62..288	CDD:238064	55/222 (25%)
		leucine-rich repeat	71..94	CDD:275380
		leucine-rich repeat	95..118	CDD:275380	2/4 (50%)
		LRR_8	117..177	CDD:290566	21/60 (35%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		LRR_8	166..222	CDD:290566	22/103 (21%)
		leucine-rich repeat	167..190	CDD:275380	10/22 (45%)
		leucine-rich repeat	191..214	CDD:275380	9/70 (13%)
		LRR_RI	214..>372	CDD:238064	49/182 (27%)
		LRR_8	214..273	CDD:290566	16/58 (28%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..262	CDD:275380	4/22 (18%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		leucine-rich repeat	287..311	CDD:275380	9/25 (36%)
		LRR_8	310..371	CDD:290566	22/83 (27%)
		leucine-rich repeat	312..334	CDD:275380	9/44 (20%)
		leucine-rich repeat	337..360	CDD:275378	6/22 (27%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	14/50 (28%)
		I-set	430..514	CDD:254352
		Ig	438..514	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910