DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Igfals

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	573	Identity:	158/573 - (27%)
Similarity:	236/573 - (41%)	Gaps:	89/573 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PLISSDTR--NCSLNACESLGIVSQLLMLINSMPNGTQSAANDKKPPKSKA---NGHNDGDVNGG 104
            |..|:|..  .|.:....|....:..|.:..|..|.||  ..|..|..::|   :|:|...:...
Mouse    65 PGASADAEGPQCPVTCTCSYDDYTDELSVFCSSRNLTQ--LPDSIPVSTRALWLDGNNLSSIPSA 127

  Fly   105 EINAMSHLANFDLVKRVRQIESRLRSVE-------QPVWHLATGSQIEWN---HCTSGVCRCNPD 159
               |..:|::.|.:...   .|.|||:|       |.::||    .:|.|   ...:|:.|..|.
Mouse   128 ---AFQNLSSLDFLNLQ---GSWLRSLEPQALLGLQNLYHL----HLERNLLRSLAAGLFRHTPS 182

  Fly   160 TKSFT-------------------CWNTNLKSVPVTQVIP-------MNMVNIDLSRNILSTLHK 198
            ..|.:                   .|:.||....:. |:|       .|:..:.|:.|.|:.|..
Mouse   183 LASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLV-VLPDTVFQGLGNLHELVLAGNKLTYLQP 246

  Fly   199 DTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKN 263
            ....||..|:|||:|.|.|..:..::|..|..|..|.:..|.:..:..|.|..::.|..||||.|
Mouse   247 ALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHN 311

  Fly   264 EIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLK 328
            .:..|.|..|.....|.|:.:..|.|.:..|...:|...||||.:..|:|.:|...:...|.:|:
Mouse   312 RVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLE 376

  Fly   329 TLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAF 393
            .|....|||.::....|.||.::..::|..|.:.||...:|..|..|.:|.|..:.:..|..:.|
Mouse   377 VLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTF 441

  Fly   394 VELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILK 458
            ..|:.|..|||..||:|||.......:|.|..|.|.:|.||.|....||||..|:.|||:||.|.
Mouse   442 AGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLT 506

  Fly   459 NFDARAFEPLSQLEKLRIDSNKL------MFLPHGALH--GLKN-----------LVAVKLDKNP 504
            ........||.:...|.:..|:|      :|...|.|.  .|:|           |..:.||.||
Mouse   507 MLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQPGLERLWLDANP 571

  Fly   505 WHCDCR-------ALYLARWIREFVLKLWDGQ--QPM-------CRGPGDLGG 541
            |.|.|.       ||.....:..||..:.:|.  ||:       |.||.::.|
Mouse   572 WDCSCPLKALRDFALQNPGVVPRFVQTVCEGDDCQPVYTYNNITCAGPANVSG 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	56/184 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	20/59 (34%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	16/57 (28%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	18/44 (41%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	7/30 (23%)
		LRRCT	503..554	CDD:214507	16/55 (29%)
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470	9/39 (23%)
		leucine-rich repeat	92..110	CDD:275380	6/19 (32%)
		PLN00113	96..>558	CDD:331614	133/474 (28%)
		leucine-rich repeat	114..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	6/25 (24%)
		leucine-rich repeat	159..182	CDD:275380	6/26 (23%)
		leucine-rich repeat	183..206	CDD:275380	1/22 (5%)
		leucine-rich repeat	207..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	6/22 (27%)
		leucine-rich repeat	447..470	CDD:275380	9/22 (41%)
		leucine-rich repeat	471..494	CDD:275380	11/22 (50%)
		leucine-rich repeat	495..516	CDD:275380	7/20 (35%)
		leucine-rich repeat	519..542	CDD:275380	4/22 (18%)
		leucine-rich repeat	543..561	CDD:275380	3/17 (18%)
		TPKR_C2	570..613	CDD:326558	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42484
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910