DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and CHADL

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	376	Identity:	103/376 - (27%)
Similarity:	147/376 - (39%)	Gaps:	64/376 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 GLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGM 267
            |||  :.||:..|:|..:|...||                .:.|.|.        |||...|:.:
Human   130 GLT--QRLDLQGNLLKVIPAAAFQ----------------GVPHLTH--------LDLRHCEVEL 168

  Fly   268 LPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDF 332
            :.|..|....||.::|:..|.::..|...|.....|..|::..|.:.||..|:
Human   169 VAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGT------------ 221

  Fly   333 GWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELN 397
                        |..|.:|.||:|.:|.:..|....|..|..:..|.|:.|.:|.:...|...|.
Human   222 ------------FGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLP 274

  Fly   398 NLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDA 462
            .|..|.|..|.:.::|..:......|.||.|..|.||....:|...|..|:.|||:...|:....
Human   275 ALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGP 339

  Fly   463 RAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWD 527
            |||....:|..|.:..|:|..||  .|.|...|..::|..||..|.|:|..|..|:....::. |
Human   340 RAFAHCPRLHTLDLRGNQLDTLP--PLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS-D 401

  Fly   528 GQQPMCRGPGDLGGHEVGLLRYDDL-CDGQWA-------SMLSLSPRLPVR 570
            |   .|:||..|.|..:..||..|| |.|..|       ......||.|.|
Human   402 G---ACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPR 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	10/37 (27%)
		leucine-rich repeat	187..206	CDD:275380	2/2 (100%)
		LRR_RI	<201..386	CDD:238064	43/182 (24%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	2/22 (9%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	13/57 (23%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	18/51 (35%)
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380	8/40 (20%)
		LRR_RI	<133..358	CDD:238064	68/272 (25%)
		LRR_8	133..214	CDD:290566	24/104 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/30 (23%)
		leucine-rich repeat	180..203	CDD:275380	5/22 (23%)
		leucine-rich repeat	204..227	CDD:275380	8/46 (17%)
		LRR_8	228..286	CDD:290566	18/57 (32%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		LRR_8	322..380	CDD:290566	19/59 (32%)
		leucine-rich repeat	324..347	CDD:275380	8/22 (36%)
		LRR_4	346..>380	CDD:289563	11/35 (31%)
		LRRNT	463..497	CDD:214470
		leucine-rich repeat	478..494	CDD:275380
		LRR_RI	492..671	CDD:238064
		leucine-rich repeat	495..518	CDD:275380
		LRR_8	518..577	CDD:290566
		leucine-rich repeat	519..542	CDD:275380
		leucine-rich repeat	543..566	CDD:275380
		LRR_8	565..625	CDD:290566
		leucine-rich repeat	567..590	CDD:275380
		leucine-rich repeat	591..614	CDD:275380
		leucine-rich repeat	615..638	CDD:275380
		LRR_8	637..698	CDD:290566
		leucine-rich repeat	639..662	CDD:275380
		leucine-rich repeat	663..687	CDD:275380
		LRR_8	686..745	CDD:290566
		leucine-rich repeat	688..712	CDD:275380
		LRR_4	711..>744	CDD:289563
		LRRCT	743..791	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840