DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Gp5

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	450	Identity:	127/450 - (28%)
Similarity:	200/450 - (44%)	Gaps:	55/450 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 IPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLR-------- 235
            :|.|:.:|.|.|.....|...:|.|:|||:.|.:|.:.:..:....|.||..|..||
Mouse    48 LPTNLTHILLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISR 112

  Fly   236 ----------------IQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINM 284
                            :.:|.|.|:|...|.:||||..|.|::|::..||.::|...:.|.::::
Mouse   113 LPRAILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDL 177

  Fly   285 CDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLR 349
            ..|.:.:.|..||..|:.||:|.:..|:::.:.||.:..|..|..|....|.:..:....|..|.
Mouse   178 SRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLG 242

  Fly   350 SLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPA 414
            :|.:|:|..|.:.||...:|.:::::..|.|..|.:..:....|.|:..|.||:|....:|::||
Mouse   243 NLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPA 307

  Fly   415 DLFLNVSALTRLTLFSN-NLTTLEADDFQGLNNLKILLLNNNILKNF--DA-------------- 462
            ..|.|:|.|..|.|..| .|:.|....||||..|::|.|:.|.|...  ||
Mouse   308 AAFRNLSGLQTLGLTRNPRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRH 372

  Fly   463 ---RA-----FEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIR 519
               ||     |..||.||.::::.|:|..||......|..|..|.|..|||.|||......:|:|
Mouse   373 NRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLR 437

  Fly   520 EFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQ-WASMLSLSPRLPVRKHQISTPM 578
            .....|...:.|.||||.....     |.:.:|..|. |.......|..|..::.:..|:
Mouse   438 HHPDILGRDEPPQCRGPEPRAS-----LSFWELLQGDPWCPDPRSLPLDPPTENALEAPV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/82 (23%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	56/208 (27%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	9/46 (20%)
		LRR_8	253..313	CDD:290566	19/59 (32%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	16/57 (28%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	17/45 (38%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	7/20 (35%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	16/50 (32%)
Gp5	NP_032174.2	LRR 1	75..96		5/20 (25%)
		LRR_8	76..134	CDD:290566	10/57 (18%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		LRR 3	123..144		5/20 (25%)
		LRR_8	124..182	CDD:290566	17/57 (30%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_RI	126..402	CDD:238064	81/275 (29%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 5	171..193		5/21 (24%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRR_8	195..254	CDD:290566	16/58 (28%)
		LRR 6	195..216		6/20 (30%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		LRR 7	219..240		4/20 (20%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		LRR_8	243..302	CDD:290566	16/58 (28%)
		LRR 8	243..264		7/20 (35%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR 9	267..288		4/20 (20%)
		leucine-rich repeat	268..291	CDD:275380	5/22 (23%)
		LRR 10	291..312		8/20 (40%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		LRR_8	314..375	CDD:290566	18/60 (30%)
		LRR 11	315..337		7/21 (33%)
		leucine-rich repeat	316..338	CDD:275380	8/21 (38%)
		LRR 12	340..361		7/20 (35%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		LRR_8	364..422	CDD:290566	15/57 (26%)
		LRR 13	364..385		3/20 (15%)
		leucine-rich repeat	365..388	CDD:275380	4/22 (18%)
		LRR 14	388..409		6/20 (30%)
		leucine-rich repeat	389..410	CDD:275380	6/20 (30%)
		TPKR_C2	421..>454	CDD:301599	12/32 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.920