DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Flii

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_071292.1	Gene:	Flii / 14248	MGIID:	1342286	Length:	1271	Species:	Mus musculus

Alignment Length:	369	Identity:	93/369 - (25%)
Similarity:	171/369 - (46%)	Gaps:	69/369 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 TNLKSVPVTQVIPMNMVNIDLSRNILSTLH-------------------------KDTFRGLTVL 207
            |.|..:|........:.::.:|.|.|:|||                         .|.|: |..|
Mouse    43 TGLCYLPEELAALQKLEHLSVSHNHLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFK-LDDL 106

  Fly   208 KELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESI 272
            ..||:|||.|...|.:| ::..::|||.:.:|.::.|.::.|..|.:|..||||:|.:..||..:
Mouse   107 SVLDLSHNQLTECPREL-ENAKNMLVLNLSHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQM 170

  Fly   273 --FYHAQRLTVIN---MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDF 332
              ..|.|.| |:|   :...|::..|..:....|.|.....:::.:..    |:..|:.|..:|.
Mouse   171 RRLVHLQTL-VLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSNLPT----SLEGLSNLSDVDL 230

  Fly   333 GWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELN 397
            ..|.:.::.:..:. |.|||.|:|.:|:|:.||..| :...:|.||:|:.|:::.:. :|..:|.
Mouse   231 SCNDLTRVPECLYT-LPSLRRLNLSSNQIAELSLCI-DQWVHLETLNLSRNQLTSLP-SAICKLT 292

  Fly   398 NLNELFLGQNSM--SSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNF 460
            .|.:|:|..|.:  ..:|:.:              ..||:||  :|...|| .:.|:..::.:
Mouse   293 KLKKLYLNSNKLDFDGLPSGI--------------GKLTSLE--EFMAANN-NLELIPESLCR-- 338

  Fly   461 DARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNP 504
                   ..:|:||.::.|:|:.||. |:|.|..:..:.:.:||
Mouse   339 -------CPKLKKLVLNKNRLVTLPE-AIHFLTEIQVLDVRENP 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/83 (27%)
		leucine-rich repeat	187..206	CDD:275380	9/43 (21%)
		LRR_RI	<201..386	CDD:238064	56/189 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	17/64 (27%)
		leucine-rich repeat	255..278	CDD:275380	9/24 (38%)
		leucine-rich repeat	279..302	CDD:275380	5/25 (20%)
		LRR_8	303..361	CDD:290566	13/57 (23%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	15/39 (38%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	10/46 (22%)
		leucine-rich repeat	399..422	CDD:275380	5/24 (21%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	10/22 (45%)
		LRRCT	503..554	CDD:214507	2/2 (100%)
Flii	NP_071292.1	Interaction with LRRFIP1 and LRRFIP2. /evidence=ECO:0000250	1..427		93/369 (25%)
		LRR_RI	<2..137	CDD:238064	24/95 (25%)
		leucine-rich repeat	10..34	CDD:275380
		LRR_8	33..91	CDD:290566	9/47 (19%)
		leucine-rich repeat	35..57	CDD:275380	3/13 (23%)
		leucine-rich repeat	58..80	CDD:275380	6/21 (29%)
		LRR_RI	89..352	CDD:238064	76/298 (26%)
		leucine-rich repeat	106..128	CDD:275380	9/22 (41%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		LRR_8	131..186	CDD:290566	19/55 (35%)
		leucine-rich repeat	153..175	CDD:275380	8/21 (38%)
		leucine-rich repeat	176..199	CDD:275380	6/23 (26%)
		leucine-rich repeat	200..224	CDD:275380	4/27 (15%)
		LRR_8	223..281	CDD:290566	19/59 (32%)
		leucine-rich repeat	225..247	CDD:275380	4/22 (18%)
		leucine-rich repeat	248..270	CDD:275380	9/22 (41%)
		leucine-rich repeat	271..318	CDD:275380	13/61 (21%)
		leucine-rich repeat	319..341	CDD:275380	6/33 (18%)
		gelsolin_S1_like	492..604	CDD:200446
		Interaction with ACTL6A. /evidence=ECO:0000250	495..827
		gelsolin_like	619..703	CDD:200436
		gelsolin_S3_like	723..837	CDD:200448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..977
		gelsolin_like	<981..1036	CDD:200436
		gelsolin_S5_like	1055..1154	CDD:200444
		Gelsolin-like 4	1070..1117
		gelsolin_S6_like	1165..1264	CDD:200447
		Gelsolin-like 5	1178..1220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910