DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lgr5

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	358	Identity:	105/358 - (29%)
Similarity:	150/358 - (41%)	Gaps:	41/358 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSF---TCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHN 215
            |.|..|.:..   .|.:..|..:|..  :.:....:|||.|.:|.|.......|..|:||.::.|
Mouse    38 CHCELDGRMLLRVDCSDLGLSELPSN--LSVFTSYLDLSMNNISQLPASLLHRLCFLEELRLAGN 100

  Fly   216 VLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLT 280
            .|..:|...|..|.||.||.:|||||..:.......||:|..|.|..|.|..:|.|.|.....|.
Mouse   101 ALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLR 165

  Fly   281 VINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFF 345
            .:.:.||.:.:.|....|....|:.:.::.|||..::                        |..|
Mouse   166 HLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIA------------------------DYAF 206

  Fly   346 AGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMS 410
            ..|.||..|.||||||.||....|:.|.:|.||||..|.:.... .|...|:||.||....|::.
Mouse   207 GNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP-TAIKTLSNLKELGFHSNNIR 270

  Fly   411 SIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLN--NNILKNFDARAFEPL---SQ 470
            |||...|:...:|..:..:.|.:..:....||.|..|:.|.||  ::|.:      |..|   :.
Mouse   271 SIPERAFVGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITE------FPHLTGTAT 329

  Fly   471 LEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            ||.|.:...|:..||......|.||..:.|..|
Mouse   330 LESLTLTGAKISSLPQAVCDQLPNLQVLDLSYN 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/58 (38%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	59/184 (32%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		LRR_8	349..407	CDD:290566	25/57 (44%)
		LRR_4	350..390	CDD:289563	19/39 (49%)
		leucine-rich repeat	351..374	CDD:275380	12/22 (55%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	1/1 (100%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470	6/33 (18%)
		leucine-rich repeat	68..91	CDD:275380	7/22 (32%)
		LRR_RI	88..386	CDD:238064	93/306 (30%)
		LRR_8	92..150	CDD:290566	23/57 (40%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_8	138..198	CDD:290566	16/59 (27%)
		leucine-rich repeat	140..163	CDD:275380	8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	5/22 (23%)
		LRR_8	188..246	CDD:290566	26/81 (32%)
		leucine-rich repeat	188..211	CDD:275380	7/46 (15%)
		leucine-rich repeat	212..235	CDD:275380	12/22 (55%)
		leucine-rich repeat	236..258	CDD:275380	8/22 (36%)
		LRR_8	257..314	CDD:290566	17/56 (30%)
		leucine-rich repeat	259..282	CDD:275380	8/22 (36%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR_8	352..410	CDD:290566	4/11 (36%)
		leucine-rich repeat	354..375	CDD:275378	3/9 (33%)
		leucine-rich repeat	376..389	CDD:275378
		leucine-rich repeat	400..423	CDD:275378
		leucine-rich repeat	445..467	CDD:275378
		7tm_1	575..820	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910