DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and CPN2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens

Alignment Length:	441	Identity:	128/441 - (29%)
Similarity:	197/441 - (44%)	Gaps:	62/441 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DTKSFTCWNTNLKSVPVTQVIPMN----------------MVNIDLSRNILSTLHKDTFRGLTVL 207
            :|::|.. |.||     |:|:.:|                :.:::::.:....|..:.|..||.|
Human    65 ETRAFGS-NPNL-----TKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSL 123

  Fly   208 KELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESI 272
            .:|.::.|:|:.||..|||.|.:|..|.:|.|||:.:..|.|..|.:|..|:|::|.:..|||.:
Human   124 GKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEEL 188

  Fly   273 FYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQI 337
            |:....|..:.:.:|.:...|..:......|:||.:..|.||||.......|..|:.|....|.|
Human   189 FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAI 253

  Fly   338 AKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNEL 402
            ..:....||.|.:|..|||..|.:..|...:|.:...||.|.||.|::..:....|..|:||..|
Human   254 THLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSL 318

  Fly   403 FLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEP 467
            .|..|:::.:||.:|.::..|.:|.|.|||||.|....||.
Human   319 MLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQN------------------------ 359

  Fly   468 LSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPM 532
            ||:||.|.:..|:|..||.|......||..:.|..|||.|||...||..|::::..:|.: .|..
Human   360 LSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTY 423

  Fly   533 CRGPGDLGGHEVGLLRYDDL-CDGQWASMLSLSPRLPVRKHQISTPMNYTD 582
            |.||..|.|..|..|....| |              ||.:..:...:.:.|
Human   424 CAGPAYLKGQVVPALNEKQLVC--------------PVTRDHLGFQVTWPD 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/74 (26%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	62/184 (34%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	18/44 (41%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	10/19 (53%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	19/51 (37%)
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470
		leucine-rich repeat	30..53	CDD:275380
		leucine-rich repeat	75..98	CDD:275380	4/27 (15%)
		LRR 1	98..119		2/20 (10%)
		leucine-rich repeat	99..122	CDD:275380	3/22 (14%)
		LRR_8	121..181	CDD:290566	24/59 (41%)
		LRR 2	122..143		8/20 (40%)
		leucine-rich repeat	123..146	CDD:275380	10/22 (45%)
		LRR 3	146..167		8/20 (40%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR_RI	149..>356	CDD:238064	67/206 (33%)
		LRR_8	169..229	CDD:290566	15/59 (25%)
		LRR 4	170..191		8/20 (40%)
		leucine-rich repeat	171..194	CDD:275380	8/22 (36%)
		LRR 5	194..215		3/20 (15%)
		leucine-rich repeat	195..218	CDD:275380	3/22 (14%)
		LRR_8	218..277	CDD:290566	21/58 (36%)
		LRR 6	218..239		8/20 (40%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR 7	242..263		5/20 (25%)
		leucine-rich repeat	243..266	CDD:275380	7/22 (32%)
		LRR 8	266..287		7/20 (35%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 9	290..311		7/20 (35%)
		leucine-rich repeat	291..314	CDD:275380	8/22 (36%)
		LRR_8	294..349	CDD:290566	19/54 (35%)
		LRR 10	314..335		8/20 (40%)
		leucine-rich repeat	315..338	CDD:275380	7/22 (32%)
		LRR 11	338..359		10/20 (50%)
		leucine-rich repeat	339..359	CDD:275380	10/19 (53%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	8/18 (44%)
		leucine-rich repeat	387..399	CDD:275378	5/11 (45%)
		LRRCT	395..446	CDD:214507	20/65 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BET7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40411
orthoMCL	1	0.900	-	-		OOG6_112811
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.630