DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LRRC15

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	452	Identity:	122/452 - (26%)
Similarity:	199/452 - (44%)	Gaps:	48/452 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 ATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPV-------------TQVIPMN-------- 182
            |.|:.:.::.|.| .|.|: ......|....:.:||.             |.:..:|
Human    21 AWGAGLAYHGCPS-ECTCS-RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 83

  Fly   183 -MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDH 246
             ::.:.:.:|.||.:....||.|..|:.|.:::|.|..||..|||.||||..|.:.:|||..|..
Human    84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148

  Fly   247 RTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRN 311
            ..|.:..||..|.|..|.:..:|:..|.|...||.:|:..|.:.:..|.:.:....|:.|.:..|
Human   149 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 213

  Fly   312 KISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLV 376
            :::::..|:...|..|:.|....|||..:....|....:|:.|.|.||.||.|..::|..|..|.
Human   214 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLN 278

  Fly   377 TLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDF 441
            .|.|..|.:..:....|..:.||.||:|..|.:||:|.::|.|:..|..|.|..|.::.:....|
Human   279 RLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 343

  Fly   442 QGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDK---- 502
            .||..|:.|.|:.|.|::.|...|..|:.|:.:.:.:|:|..||......:..|:|::|..
Human   344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 408

  Fly   503 --------------------NPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEV 544
                                |||.||...|.|..|:.....:|.....|:|..|.::.|..:
Human   409 NLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/67 (33%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	60/184 (33%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	10/22 (45%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	16/44 (36%)
		leucine-rich repeat	399..422	CDD:275380	10/22 (45%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	13/42 (31%)
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	11/58 (19%)
		LRR_RI	63..309	CDD:238064	71/245 (29%)
		LRR_8	88..167	CDD:290566	30/78 (38%)
		leucine-rich repeat	88..108	CDD:275380	6/19 (32%)
		leucine-rich repeat	109..156	CDD:275380	19/46 (41%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR_8	180..239	CDD:290566	13/58 (22%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		LRR_8	228..287	CDD:290566	20/58 (34%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	22/59 (37%)
		LRR_4	299..340	CDD:289563	15/40 (38%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		LRR_4	324..364	CDD:289563	12/39 (31%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		leucine-rich repeat	349..370	CDD:275380	7/20 (35%)
		LRR_8	372..430	CDD:290566	8/57 (14%)
		leucine-rich repeat	373..393	CDD:275380	5/19 (26%)
		leucine-rich repeat	397..418	CDD:275380	3/20 (15%)
		TPKR_C2	429..>468	CDD:301599	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4083
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40411
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.970