DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and TOLL7

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_320221.4	Gene:	TOLL7 / 1280374	VectorBaseID:	AGAP012326	Length:	1268	Species:	Anopheles gambiae

Alignment Length:	428	Identity:	113/428 - (26%)
Similarity:	200/428 - (46%)	Gaps:	41/428 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DVNGGEINAMSHLANFDL------------------VKRVRQIESRLRSVEQPVWHLATGSQIEW 146
            ::..|.:..:..|.:.||                  :|.:....:|.||.|      |.|  :..
Mosquito   104 ELQAGSMRGLKELQSLDLSDNNIRALPDGFLCPLTGLKVLNLTNNRFRSAE------ALG--LAE 160

  Fly   147 NHCTSGVCRCNPDTKSFTCWNTNLKSVP----VTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVL 207
            ..|..|     .:.::.......|:|||    |:::..:..:|::.  |.:|.:|.|...||..|
Mosquito   161 KSCPGG-----SELQALNLAYNELRSVPTGWGVSKLRRLQHLNLEF--NNISEVHGDALAGLGSL 218

  Fly   208 KELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGM--LPE 270
            :.|::|:|.|:.||..||.....|..:.:|.||:.::....|.:|..|.:||||:|::..  :..
Mosquito   219 RTLNLSYNHLETLPGGLFAGSRDLREIHLQGNQIYELPRGLFHRLEQLLVLDLSRNQLSSHHVDN 283

  Fly   271 SIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWN 335
            ..|....||.|:|:..|.:.........:...|:.||:..|.|..:...:...:..|.||:...|
Mosquito   284 GTFSGLIRLVVLNLAHNALTRIDARTFAELYFLQILDLRNNSIGYIEDNAFLPVYNLHTLNLAEN 348

  Fly   336 QIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLN 400
            ::..:||..|.||..|..|:|:||.||.:...:|.|.::|..|||::|:::.:. .|..:|:.|.
Mosquito   349 RLHTLDDRLFNGLFVLSKLTLNNNLISIVEPNVFRNCSDLKELDLSSNQLTEVP-YAIRDLSMLR 412

  Fly   401 ELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAF 465
            .|.||:|.::.|....|.|::.||.|.|..|.:..:....|..|..|.:|.|..|.::|.:..:|
Mosquito   413 ALDLGENQIARIENGTFANLNQLTGLRLIDNQIENVTVGMFADLPRLSVLNLAKNRVQNIERGSF 477

  Fly   466 EPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            :....:|.:|:|.|.|..: :|....|.:|:.:.|.:|
Mosquito   478 DRNLDIEAIRLDGNFLTDI-NGIFATLASLLWLNLAEN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	57/186 (31%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	16/61 (26%)
		leucine-rich repeat	255..278	CDD:275380	7/24 (29%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	19/57 (33%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	14/44 (32%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	1/1 (100%)
TOLL7	XP_320221.4	leucine-rich repeat	61..84	CDD:275380
		LRR_8	63..126	CDD:290566	4/21 (19%)
		leucine-rich repeat	85..115	CDD:275380	1/10 (10%)
		LRR_RI	114..328	CDD:238064	56/228 (25%)
		leucine-rich repeat	116..139	CDD:275380	3/22 (14%)
		LRR_8	138..204	CDD:290566	16/80 (20%)
		leucine-rich repeat	169..193	CDD:275380	5/23 (22%)
		LRR_8	192..252	CDD:290566	19/61 (31%)
		leucine-rich repeat	194..217	CDD:275380	7/24 (29%)
		leucine-rich repeat	218..241	CDD:275380	9/22 (41%)
		LRR_8	242..302	CDD:290566	18/59 (31%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		leucine-rich repeat	266..291	CDD:275380	7/24 (29%)
		LRR_8	291..350	CDD:290566	14/58 (24%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		LRR_RI	302..587	CDD:238064	61/215 (28%)
		leucine-rich repeat	316..339	CDD:275380	5/22 (23%)
		LRR_8	339..398	CDD:290566	23/58 (40%)
		leucine-rich repeat	340..363	CDD:275380	9/22 (41%)
		leucine-rich repeat	364..387	CDD:275380	9/22 (41%)
		LRR_8	388..445	CDD:290566	20/57 (35%)
		LRR_4	388..426	CDD:289563	13/38 (34%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..458	CDD:275380	7/22 (32%)
		LRR_8	457..516	CDD:290566	16/59 (27%)
		leucine-rich repeat	459..482	CDD:275380	6/22 (27%)
		leucine-rich repeat	483..503	CDD:275380	6/20 (30%)
		leucine-rich repeat	575..598	CDD:275378
		TPKR_C2	638..694	CDD:301599
		leucine-rich repeat	758..780	CDD:275380
		LRR_8	779..839	CDD:290566
		leucine-rich repeat	781..804	CDD:275380
		LRR_RI	804..>889	CDD:238064
		leucine-rich repeat	805..828	CDD:275380
		LRR_8	829..890	CDD:290566
		leucine-rich repeat	829..852	CDD:275380
		leucine-rich repeat	853..880	CDD:275380
		TIR	1007..1146	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910