DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP011371

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_317948.4	Gene:	AgaP_AGAP011371 / 1278325	VectorBaseID:	AGAP011371	Length:	320	Species:	Anopheles gambiae

Alignment Length:	327	Identity:	97/327 - (29%)
Similarity:	157/327 - (48%)	Gaps:	22/327 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 LRIQNNQLEDIDHR-TFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLL 297
            |.|:.|:::.||.. .|:  ..|.:||||.|.:..:||.||.:.::|..:::.:|::........
Mosquito     2 LVIKFNRIKSIDSSIQFY--TELTMLDLSYNHLLSIPERIFMYQKKLLQLHLNNNKLGAVTNRTF 64

  Fly   298 RDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRS--LRTLSLHNNR 360
            .....|..|::..|.|.|:.|...:.|.||:.|:.|.|:||.:....|.||.:  ||.|.:|.:.
Mosquito    65 GGLDELRVLNLRGNFIDEIGSELFKALPKLEELNLGQNRIATLHASAFDGLANLRLRRLDIHGSM 129

  Fly   361 ISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTR 425
            :.:::...|..|.|:.:|||:.|.:..:.......|..|.||.:|||...:||...|..:|.|..
Mosquito   130 LVNITSDTFRGLENIRSLDLSDNHLLKVPTVQLSGLKRLEELTIGQNDFETIPEGAFFGLSNLKS 194

  Fly   426 LTLF-SNNLTTLEADDFQGLNNLK-ILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGA 488
            :.:. :.||..:::..|....||: |.:.:|..|...|..||..|..:.|:.:..||:... |..
Mosquito   195 IDISGALNLRQVQSGAFSANPNLESITIASNKELLELDEGAFAGLPHIRKVSLRDNKIATF-HEE 258

  Fly   489 LHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLK---LWDGQ----QPMCRGPGDLGGHEVGL 546
            |...|:|....|.:||..|||..|    |:|..:.:   ..:||    |.:|.||..|.|.   |
Mosquito   259 LLPWKHLAEFDLTENPLVCDCNVL----WLRNLLQRQRAASEGQDDLAQLVCSGPDRLHGE---L 316

  Fly   547 LR 548
            ||
Mosquito   317 LR 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	3/6 (50%)
		leucine-rich repeat	187..206	CDD:275380
		LRR_RI	<201..386	CDD:238064	46/154 (30%)
		leucine-rich repeat	207..230	CDD:275380
		leucine-rich repeat	231..254	CDD:275380	6/20 (30%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		LRR_8	303..361	CDD:290566	21/59 (36%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	16/59 (27%)
		LRR_4	350..390	CDD:289563	11/41 (27%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	14/45 (31%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	4/20 (20%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	19/53 (36%)
AgaP_AGAP011371	XP_317948.4	leucine-rich repeat	1..21	CDD:275380	6/20 (30%)
		LRR_8	20..78	CDD:290566	14/57 (25%)
		LRR_RI	<22..156	CDD:238064	40/133 (30%)
		leucine-rich repeat	22..45	CDD:275380	10/22 (45%)
		leucine-rich repeat	46..69	CDD:275380	2/22 (9%)
		LRR_8	69..130	CDD:290566	21/60 (35%)
		leucine-rich repeat	70..93	CDD:275380	7/22 (32%)
		leucine-rich repeat	94..117	CDD:275380	9/22 (41%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		LRR_8	143..199	CDD:290566	17/55 (31%)
		leucine-rich repeat	144..167	CDD:275380	5/22 (23%)
		LRR_5	168..>250	CDD:290045	24/81 (30%)
		leucine-rich repeat	168..191	CDD:275380	9/22 (41%)
		leucine-rich repeat	192..216	CDD:275380	4/23 (17%)
		leucine-rich repeat	217..241	CDD:275380	8/23 (35%)
		leucine-rich repeat	242..260	CDD:275380	4/18 (22%)
		LRRCT	273..320	CDD:214507	19/53 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910