DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP008593

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_314696.4	Gene:	AgaP_AGAP008593 / 1275449	VectorBaseID:	AGAP008593	Length:	604	Species:	Anopheles gambiae

Alignment Length:	474	Identity:	115/474 - (24%)
Similarity:	194/474 - (40%)	Gaps:	110/474 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 PKSKANG--HNDGDVNGGEINAMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHC-- 149
            |..:||.  :...|:...|.|        |.|.........||::.:   |......|:.|||
Mosquito    17 PAGEANALPYGAADIELDEAN--------DAVSLTACYVEDLRNIRE---HSQNPLVIQINHCYL 70

  Fly   150 ---------------TSGVC--RCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLH 197
                           ...:|  |.|           ||:...:..:  .|:.:::||||.|:|:.
Mosquito    71 QELPNAIFIRFTDLKVLEICDSRVN-----------NLQDFALNGL--RNIESLNLSRNNLTTIK 122

  Fly   198 KDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSK 262
            ..:...|..|:.||:..|::..:....||....|:.|.:..|.:..:...||..:.||..|:|.|
Mosquito   123 SWSDHDLGTLQVLDLRRNLIRSIDELSFQRYPGLVKLSLAVNFITTVPDGTFKPVANLKNLNLGK 187

  Fly   263 NEIGMLPES----------IFYHAQR--------------LTVINMCDNQIQNFPPNLLRDQLML 303
            |.:..:.|.          :.:|..|              |.|:.:..||:.:|.|:|..:...|
Mosquito   188 NLLTTIEEGTLRGLNKLTHVAFHHNRIRTIHPFAFVGNGHLKVLQLQGNQLGSFEPDLFGNLPRL 252

  Fly   304 EELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTI 368
            ..|::|.|::..:.:.|.:....|:.||..:|:|..::|:.|.||..|..|::.:|:::::|..:
Mosquito   253 TFLNVSSNELETVGNLSFKNSGDLRVLDLSYNRIGLLEDNSFKGLYDLEALNVSHNQLATVSKYV 317

  Fly   369 FNNLANLVTLDLTTNRISHID---GNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFS 430
            ..:.|||..|||:.||:.::.   .:|...|..||   |.:|::..|..|:|.::..|..|.|..
Mosquito   318 LKDCANLRDLDLSGNRLDYVGLKLSSATPRLVRLN---LSRNAIGEIERDVFEDLPKLHTLDLAH 379

  Fly   431 NNLTTLEADD--FQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLK 493
            |.||    ||  ...|.||.:|.::.|..:..:|...|.|:..|
Mosquito   380 NQLT----DDAFLWSLMNLSVLNMSQNGFRKINASLLESLTLAE--------------------- 419

  Fly   494 NLVAVKLDKNPWHCDCRAL 512
                  |..|||  |||.|
Mosquito   420 ------LYDNPW--DCRFL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/58 (29%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	54/208 (26%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	20/83 (24%)
		leucine-rich repeat	255..278	CDD:275380	7/32 (22%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	303..361	CDD:290566	17/57 (30%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	17/60 (28%)
		LRR_4	350..390	CDD:289563	12/42 (29%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		leucine-rich repeat	375..398	CDD:275380	8/25 (32%)
		LRR_8	398..>443	CDD:290566	15/46 (33%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	8/21 (38%)
		leucine-rich repeat	471..494	CDD:275380	1/22 (5%)
		LRRCT	503..554	CDD:214507	7/10 (70%)
AgaP_AGAP008593	XP_314696.4	LRR_8	84..142	CDD:290566	17/70 (24%)
		leucine-rich repeat	84..107	CDD:275380	5/35 (14%)
		LRR_4	107..149	CDD:289563	12/41 (29%)
		leucine-rich repeat	109..131	CDD:275380	7/21 (33%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	5/22 (23%)
		LRR_8	179..238	CDD:290566	12/58 (21%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		LRR_RI	227..>424	CDD:238064	60/230 (26%)
		LRR_8	227..286	CDD:290566	16/58 (28%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	276..334	CDD:290566	20/57 (35%)
		leucine-rich repeat	276..299	CDD:275380	9/22 (41%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		LRR_8	323..382	CDD:290566	20/61 (33%)
		leucine-rich repeat	324..347	CDD:275380	7/22 (32%)
		leucine-rich repeat	348..369	CDD:275380	8/23 (35%)
		leucine-rich repeat	372..393	CDD:275380	9/24 (38%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910